Target Name: GPR149
NCBI ID: G344758
Review Report on GPR149 Target / Biomarker Content of Review Report on GPR149 Target / Biomarker
GPR149
Other Name(s): R35 | GP149_HUMAN | IEDA | Probable G-protein coupled receptor 149 | G protein-coupled receptor 149 | G-protein coupled receptor PGR10 | PGR10 | G protein-coupled receptor PGR10

Identification of Potential Drug Targets for GPR149

GPR149 (R35) is a G protein-coupled receptor (GPCR) that is expressed in various tissues and cells throughout the body. It is a key regulator of cell-cell interactions, including the development and maintenance of tissues and organs, as well as the regulation of physiological processes such as inflammation and metabolism.

GPR149 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its function as a GPCR has also led to a growing interest in its potential as a therapeutic agent for treating a variety of conditions.

One of the key challenges in studying GPR149 is its expression and function, as it is expressed in a wide range of tissues and cells and can be difficult to target specifically. However, research into its function has led to the identification of several potential drug targets that can interact with GPR149.

One of the most promising targets for GPR149 is the protein p120GAP, which is a known GPCR-interactor. p120GAP is a protein that is involved in a variety of cellular processes, including cell-cell signaling, cell survival, and cell growth. It is also known to interact with several other GPCRs, including GPR149.

Research has shown that the p120GAP-GPR149 interaction plays a role in regulating cellular processes that are important for the development and maintenance of tissues and organs, as well as the regulation of inflammation and metabolism. This suggests that targeting GPR149 with a drug that can inhibit the activity of p120GAP could be a promising strategy for treating a variety of diseases.

Another potential drug target for GPR149 is the protein NF-kappa-B, which is a transcription factor that is involved in a wide range of cellular processes, including inflammation, pain, and metabolism. NF-kappa-B is known to interact with GPCRs, including GPR149, and is involved in the regulation of cellular processes that are important for the development and maintenance of tissues and organs.

Research has shown that the NF-kappa-B-GPR149 interaction plays a role in the regulation of cellular processes that are important for the development and maintenance of tissues and organs, as well as the regulation of inflammation and metabolism. This suggests that targeting GPR149 with a Drug that can inhibit the activity of NF-kappa-B could be a promising strategy for treating a variety of diseases.

Another potential drug target for GPR149 is the protein TGF-β, which is a transcription factor that is involved in a wide range of cellular processes, including cell growth, differentiation, and inflammation. TGF-β is known to interact with GPCRs, including GPR149 , and is involved in the regulation of cellular processes that are important for the development and maintenance of tissues and organs.

Research has shown that the TGF-β-GPR149 interaction plays a role in the regulation of cellular processes that are important for the development and maintenance of tissues and organs, as well as the regulation of inflammation and metabolism. This suggests that targeting GPR149 with a Drug that can inhibit the activity of TGF-β could be a promising strategy for treating a variety of diseases.

In conclusion, GPR149 is a GPCR that is involved in a wide range of cellular processes that are important for the development and maintenance of tissues and organs, as well as the regulation of inflammation and metabolism. Its function as a GPCR has led to a growing interest in its potential as a therapeutic agent for a variety of diseases. The identification of several potential drug targets, including p120GAP, NF-kappa-B, and TGF-β, has further

Protein Name: G Protein-coupled Receptor 149

Functions: Orphan receptor

The "GPR149 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR149 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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