IL-7: A Potential Drug Target for Various Diseases (G3574)

Target Name: IL7

NCBI ID: G3574

Content of Review Report on IL7 Target / Biomarker

IL7

IL-7: A Potential Drug Target for Various Diseases

IL-7 (Interleukin-7) is a cytokine that plays a crucial role in the immune system and has been identified as a potential drug target for various diseases. IL-7 is a pro-inflammatory cytokine that is produced by various cell types in the body, including T cells, natural killer cells, and monocytes. It is involved in the regulation of immune responses, cell proliferation, and survival.

One of the key functions of IL-7 is its ability to stimulate the production of other cytokines and chemokines, which are important molecules that help coordinate the immune response. IL-7 has been shown to play a key role in the regulation of T cell development and activation, as well as in the regulation of immune cell proliferation and survival.

In addition to its role in immune regulation, IL-7 has also been shown to have a variety of other functions in the body. For example, it has been shown to play a key role in the regulation of inflammation, both acute and chronic. IL-7 has been shown to promote the recruitment of immune cells to sites of inflammation and to stimulate the production of pro-inflammatory cytokines. It has also been shown to play a key role in the regulation of pain perception and the modulation of pain sensitivity.

Despite its potential as a drug target, IL-7 has yet to be fully characterized and its role in various diseases is not yet fully understood. However, research into IL-7 and its potential as a drug target is ongoing, and there is growing interest in developing compounds that can inhibit the activity of IL-7 and its downstream targets.

One approach to targeting IL-7 as a drug is to develop small molecules that can inhibit the activity of IL-7R, a protein that is involved in the regulation of IL-7 signaling. IL-7R is a G protein-coupled receptor ( GPCR), which means that it is involved in the regulation of intracellular signaling pathways. GPCRs are a family of transmembrane proteins that are involved in the regulation of a wide range of cellular processes, including sensory perception, neurotransmission, and hormone signaling.

At present, some drugs targeting IL-7 have entered clinical research, such as the use of IL-7 antagonists to treat autoimmune diseases and inflammatory diseases. In addition, interferons targeting IL-7 are also being studied. These drug studies have shown that IL-7 has immunogenic and inflammatory effects and can regulate and promote the activity of immune cells, thus posing a potential threat to human health. Therefore, future research should study IL-7 in a comprehensive and in-depth manner to better understand its function and mechanism of action and to develop more effective treatments.

Protein Name: Interleukin 7

Functions: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:7527823, PubMed:25870237). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231). Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:20974963)

The "IL7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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