ILVBL: Key Protein Regulating Acetyl-CoA Levels and Energy Metabolism

Target Name: ILVBL

NCBI ID: G10994

ILVBL

ILVBL: Key Protein Regulating Acetyl-CoA Levels and Energy Metabolism

ILVBL (acetolactate synthase-like protein) is a protein that is expressed in various tissues throughout the body, including the liver, muscle, and heart. It is a key player in the metabolism of acetyl-CoA, a crucial intermediate step in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle. This cycle is responsible for generating energy in the form of ATP from the breakdown of food by the body.

ILVBL is a member of the superfamily of proteins known as Acetyl-CoA synthases, which are involved in the production of acetyl-CoA from various precursors, including carbon sources such as glucose, fatty acids, or amino acids. These enzymes are critical for maintaining energy homeostasis and have been implicated in a wide range of physiological processes, including metabolism, inflammation, and development.

ILVBL is a 26-kDa protein that is expressed in human tissues and has been shown to play a crucial role in the regulation of acetyl-CoA levels. It is highly expressed in the liver, muscle, and heart, and has been shown to localize to the endoplasmic reticulum (ER) in these tissues. In addition, ILVBL has been shown to be involved in the regulation of cellular signaling pathways, including the TCA cycle and the metabolic pathways that are involved in the production of energy from food.

One of the key functions of ILVBL is its role in the regulation of acetyl-CoA levels. Acetyl-CoA is a key player in the TCA cycle and is involved in the production of ATP and other high-energy molecules. The levels of acetyl-CoA in the body are regulated by various enzymes, including the TCA cycle enzymes, which are dependent on the availability of acetyl-CoA. The activity of these enzymes is regulated by various factors, including the levels of acetyl-CoA and the levels of ATP. ILVBL is involved in the regulation of acetyl-CoA levels by participating in the production of ATP from the breakdown of acetyl-CoA.

In addition to its role in the regulation of acetyl-CoA levels, ILVBL is also involved in the regulation of cellular signaling pathways. It has been shown to be involved in the regulation of several signaling pathways, including the TCA cycle, the electron transport chain, and the G protein-coupled receptor (GPCR) signaling pathway. These signaling pathways are involved in the regulation of a wide range of cellular processes, including metabolism, cell growth, and stress response.

The role of ILVBL in the regulation of acetyl-CoA levels and cellular signaling pathways is further supported by its expression in tissues that are involved in energy metabolism, such as the liver and muscle. The liver is a key organ involved in the metabolism of acetyl-CoA, and the levels of ILVBL in the liver are shown to be closely correlated with the levels of acetyl-CoA. Similarly, muscle is involved in the production of ATP, which is the primary source of energy for muscle fibers. The levels of ILVBL in muscle fibers are shown to be closely correlated with the levels of ATP.

The potential clinical applications of ILVBL as a drug target or biomarker are vast. One of the main targets of ILVBL is the treatment of metabolic disorders, such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). These disorders are characterized by high levels of acetyl-CoA and associated with a range of cardiovascular and metabolic complications. By targeting ILVBL, drugs could potentially reduce the production of acetyl-CoA and improve energy metabolism, leading to a reduction in the risk of cardiovascular

Protein Name: IlvB Acetolactate Synthase Like

Functions: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway

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