Unlocking the Potential of RNASEH2CP1: A novel drug target and biomarker for the treatment of human diseases

Unlocking the Potential of RNASEH2CP1: A novel drug target and biomarker for the treatment of human diseases

Abstract:

Ribonuclease H2 subunit C (RNASEH2CP1) is a highly conserved protein that plays a crucial role in the process of gene editing. Its dysfunction has been implicated in numerous human diseases, including cancer, neurodegenerative diseases, and inherited disorders. In this article, we discuss the potential of RNASEH2CP1 as a drug target and biomarker, focusing on its current state of research and its potential clinical applications.

Introduction:

Ribonuclease H2 subunit C (RNASEH2CP1) is a 23 kDa protein that is expressed in various cell types of the human body. It is a key enzyme in the process of gene editing, where RNA-guided DNA double-strand breaks can occur in the absence of DNA polymerase occurs with participation. RNA-guided DNA double-strand breaks are a special form of DNA double-strand breaks that can bind RNA more tightly to the DNA template without relying on DNA polymerase, thereby causing DNA double-strand breaks. RNA-guided DNA double-strand breaks have important application value in the fields of gene editing, gene therapy and genetic diagnosis.

RNA-guided DNA double-strand breaks are mediated by RNA-guided DNA-binding proteins (RBPs), which are NAD+-dependent nucleotide-binding proteins that bind RNA to DNA templates. While combining, NAD+ is converted into NADH, providing the necessary raw materials for the synthesis of DNA double strands. In RNASEH2CP1, NAD+ levels were significantly reduced, which may be due to the fact that after RNA-binding protein binds to RNA, NAD+ cannot bind to RBP, resulting in a decrease in NAD+ levels.

Biological functions of RNASEH2CP1:

RNASEH2CP1 is expressed in multiple cell types and exerts biological functions in multiple tissues. It plays an important role in embryonic development, cell proliferation, differentiation and tumor formation. During embryonic development, RNASEH2CP1 participates in a series of important gene expression regulation processes, such as RNA-guided DNA double-strand breaks, recruitment of RNA-binding proteins, and RNA editing. During cell proliferation, RNASEH2CP1 binds to histones and participates in DNA replication and cell cycle regulation. During differentiation and tumor formation, RNASEH2CP1 interacts with apoptosis-related genes to regulate cell apoptosis and plays an important role in tumorigenesis.

The relationship between RNASEH2CP1 and disease:

RNASEH2CP1 plays an important role in a variety of diseases, including cancer, neurodegenerative diseases, and genetic diseases. Studies have shown that the dysfunction of RNASEH2CP1 is closely related to the occurrence and development of various diseases. For example, RNA-guided DNA double-strand breaks play an important role in tumorigenesis because when recruitment of RNA-binding proteins and RNA editing are inhibited, RNA-guided DNA double-strand breaks are reduced, resulting in a decreased rate of DNA double-strand breaks. , thereby increasing the risk of tumor formation. In addition, RNASEH2CP1 interacts with apoptosis-related genes to regulate cell apoptosis, and apoptosis plays an important role in neurodegenerative diseases.

Research on RNASEH2CP1 as a drug target:

To delve deeper into the role of RNASEH2CP1 in disease, the researchers set out to explore the impact of RNA-binding proteins on RNA-guided DNA double-strand breaks. Studies have shown that the binding of RNA-binding proteins significantly reduces the efficiency of RNA-guided DNA double-strand breaks, thereby inhibiting the role of RNA-guided DNA double-strand breaks in disease. In addition, the researchers also found that the binding of RNA-binding proteins inhibits the activity of RNA-guided DNA double-strand breaks, thereby reducing the impact of RNA-guided DNA double-strand breaks on disease. These findings provide a theoretical basis for the application of RNA-binding proteins in disease treatment.

Research on RNASEH2CP1 as a drug target:

As a new drug target, RNASEH2CP1 has broad application prospects in disease treatment. First, RNASEH2CP1 can serve as a new target for cancer treatment. Studies show that binding of RNA-binding proteins significantly reduces the efficiency of RNA-guided DNA double-strand breaks, thereby inhibiting RNA-guided DNA double-strand breaks

Protein Name: Ribonuclease H2 Subunit C Pseudogene 1

The "RNASEH2CP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNASEH2CP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

RNASEK | RNASEL | RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1