Unlocking the Potential of CACNA1E as a Drug Target and Biomarker

Target Name: CACNA1E

NCBI ID: G777

CACNA1E

Unlocking the Potential of CACNA1E as a Drug Target and Biomarker

Introduction

CACNA1E, a calcium channel that plays a crucial role in neurotransmitter release and neuromodulation, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. Its function and regulation have been extensively studied, providing a foundation for the development of new therapeutic approaches. In this article, we will explore the biology and potential applications of CACNA1E, with a focus on its role as a drug target and biomarker.

CACNA1E: Structure and Function

CACNA1E is a member of the calcium channel subfamily R, which includes several related proteins that share a common catalytic mechanism for channel opening and closure. These proteins act as ion channels, allowing specific ions to enter or exit the cell in response to changes in membrane potential. CACNA1E is characterized by its alpha-1 polypeptide, which consists of four 伪-helices and a unique C-terminus that is involved in its stability and interactions with other proteins.

CACNA1E is expressed in a variety of tissues, including neurons, muscle cells, and the nervous system, and its function is crucial for the regulation of neurotransmitter release and neuromodulation. During its GDP-dependent activation state, CACNA1E forms a 400-angstrom-long of the 尾-helix and form two interacting helices-尾, which result in changes in the transmembrane potential. In the inactive state, the C-terminus of CACNA1E interacts with the protein, maintaining its stability and affecting its function.

The mechanism of action of CACNA1E is not fully understood, but research shows that it is involved in a series of important neural processes, such as nerve impulse transmission, muscle contraction, cell proliferation and differentiation, etc. In the process of nerve impulse transmission, the role of CACNA1E is crucial because it is directly involved in the formation and maintenance of action potentials. At the same time, CACNA1E is also closely related to the survival and apoptosis of neurons and plays an important role in neurodegenerative diseases.

CACNA1E as a Drug Target

CACNA1E's unique structure and function make it an attractive drug target for the development of new therapeutic agents. Several studies have identified potential drug-like molecules that can interact with CACNA1E and modulate its function. One of the most promising strategies is the use of small molecules that can modulate the activity of CACNA1E, such as amyloid precursor protein (APP), which has been shown to interact with CACNA1E and enhance its activity.

Another approach is the use of antibodies that can specifically target CACNA1E and modulate its function. These antibodies have been shown to interact with CACNA1E and can either activate or inhibit its activity, depending on the specific context. The use of antibodies is a promising strategy for the development of new therapeutic approaches, as it allows for the targeted delivery of drugs to specific target cells.

CACNA1E as a Biomarker

CACNA1E's unique structure and function also make it an attractive biomarker for the diagnosis and monitoring of various neurological and psychiatric disorders. Its expression patterns and activity have been extensively studied, providing valuable information for the development of biomarkers.

One of the most promising biomarkers for CACNA1E is its expression level. Studies have shown that the expression of CACNA1E is affected by a variety of factors, including neurological disorder, age, and treatment. By monitoring the expression of CACNA1E, researchers can gain insights into the underlying mechanisms of neurological disorders and develop new diagnostic or therapeutic approaches.

Another promising biomarker for CACNA1E is its activity. Studies have shown that CACNA1E's activity can be modulated by various factors, including drugs, behavioral changes, and neurological disorders. By monitoring CAC

Protein Name: Calcium Voltage-gated Channel Subunit Alpha1 E

Functions: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing

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