Calcium-Gated Channel CACNA1D: A Promising Drug Target (G776)

Target Name: CACNA1D

NCBI ID: G776

CACNA1D

Calcium-Gated Channel CACNA1D: A Promising Drug Target

Unlocking the Potential of Calcium-Gated Channels as Drug Targets: A Comprehensive Review of CACNA1D and its Potential as a Calcium-Sensitive Molecule

Abstract:

Calcium-gated channels have emerged as a promising drug target class due to their modulation by various chemical compounds, including small molecules, peptides, and even drugs. One such channel subunit, CACNA1D, has been identified as a potential drug target due to its unique calcium-sensitive properties. In this article, we will review the current research on CACNA1D, including its structure, function, and potential as a drug target.

Introduction:

Calcium channels are a critical modulator of various physiological processes, including muscle contractions, nerve impulse conduction, and secretion. The calcium-gated channel is the most well-studied channel subunit and is responsible for the majority of the channel function. The alpha1 D variant of the calcium-gated channel subunit, CACNA1D, has unique properties that make it an attractive drug target.

Structure and Function:

CACNA1D is a member of the universal protein family (U family) of calcium channels, which are characterized by the presence of a unique transmembrane segment (TMS) and a unique catalytic domain. The TMS is a critical region that plays a crucial role in the channel's stability and functions. CACNA1D has a unique TMS that is rich in glutamate and glutamine, which are known for their ability to modulate the activity of other channels.

In addition to its unique TMS, CACNA1D has a unique catalytic domain that is characterized by a long amino acid sequence that includes a putative nucleotide-binding site (NBS) and a putative ion-binding site (IBS). The NBS is known for its role in nucleotide recognition, while the IBS is known for its role in ion recognition and channel function.

CACNA1D's unique structure and function have led to its potential as a drug target. One of the most promising strategies for targeting CACNA1D is the use of small molecules that can modulate its activity. Many small molecules have been shown to modulate the activity of CACNA1D, including inhibitors of sodium channels and channels that are closely related to CACNA1D. Additionally, CACNA1D has been shown to be sensitive to various types of drugs, including inhibitors of ion channels, neurotransmitters, and even drugs that affect the TMS.

Potential as a Drug Target:

The potential of CACNA1D as a drug target is due to its unique properties, including its calcium-sensitivity and its unique structure and function. CACNA1D's calcium-sensitivity makes it an attractive target for drugs that act on calcium channels. Additionally, its unique structure and function has led to its resistance to many common inhibitors of channels, making it a challenging target.

One of the most promising strategies for targeting CACNA1D is the use of small molecules that can modulate its activity. Many small molecules have been shown to modulate the activity of CACNA1D, including inhibitors of sodium channels and channels that are closely related to CACNA1D. For example , inhibitors of the sodium channel known as SEN1 have been shown to be particularly effective in blocking the activity of CACNA1D. Additionally, inhibitors of the calcium channel known as troponin have been shown to be effective in blocking the activity of CACNA1D.

Another promising strategy for targeting CACNA1D is the use of drugs that affect its TMS. Many drugs have been shown to affect the TMS of CAC

Protein Name: Calcium Voltage-gated Channel Subunit Alpha1 D

Functions: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines

The "CACNA1D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CACNA1D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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