CACNA2D4: A Calcium-Mediated Channel Auxiliary Subunit Alpha2delta 4 as a Potential Drug Target and Biomarker

Target Name: CACNA2D4

NCBI ID: G93589

CACNA2D4

Other Name(s): Calcium voltage-gated channel auxiliary subunit alpha2delta 4 | alpha2delta-4 | CA2D4_HUMAN | calcium channel, voltage-dependent, alpha 2/delta subunit 4 | Voltage-dependent calcium channel subunit alpha-2-4 | Voltage-dependent calcium channel subunit alpha-2/delta-4 | Voltage-dependent calcium channel subunit delta-4 | calcium voltage-gated channel auxiliary subunit alpha2delta 4 | RCD4 | voltage-gated calcium channel alpha(2)delta-4 subunit | Voltage-gated calcium channel subunit alpha-2/delta-4 | voltage-gated calcium channel subunit alpha-2/delta-4

CACNA2D4: A Calcium-Mediated Channel Auxiliary Subunit Alpha2delta 4 as a Potential Drug Target and Biomarker

Abstract:

CACNA2D4, the calcium-mediated channel auxiliary subunit alpha2delta 4, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. This gene, encoding a protein involved in synaptic plasticity and neurotransmission, has been shown to regulate the activity of several neurotransmitter systems, including dopamine, serotonin, and GABA. The calcium-mediated channel auxiliary subunit alpha2delta 4 dysfunction has been implicated in the pathophysiology of various psychiatric and neurological disorders, including depression, anxiety, and schizophrenia. Therefore, the study of CACNA2D4 as a potential drug target and biomarker has significant implications for the development of new therapeutic strategies for these disorders.

Introduction:

CACNA2D4, the calcium-mediated channel auxiliary subunit alpha2delta 4, is a gene that encodes a protein involved in synaptic plasticity and neurotransmission. The alpha2delta 4 subunit is a key component of the voltage-gated channel, which is a critical protein involved in neurotransmission. The voltage-gated channel is a transmembrane protein that plays a central role in neurotransmission by allowing the passage of charged particles, such as neurotransmitters, into the cell. The alpha2delta 4 subunit is involved in regulating the activity of the voltage-gated channel, allowing it to modulate the neurotransmission.

CACNA2D4 is expressed in various tissues and cell types, including the brain. It has been shown to be involved in the regulation of neurotransmitter release and synaptic plasticity. The alpha2delta 4 subunit has been shown to play a role in the regulation of dopamine release from the prefrontal cortical neurons. Furthermore, the alpha2delta 4 subunit has been implicated in the regulation of serotonin and GABA release from the postsynaptic neurons.

Despite the significant involvement of CACNA2D4 in neurotransmission, the precise mechanism of its regulation remains poorly understood. The calcium-mediated channel auxiliary subunit alpha2delta 4 dysfunction has been implicated in the pathophysiology of various psychiatric and neurological disorders, including depression, anxiety, and schizophrenia. Therefore, the study of CACNA2D4 as a potential drug target and biomarker has significant implications for the development of new therapeutic strategies for these disorders.

CACNA2D4 as a Drug Target:

The alpha2delta 4 subunit of CACNA2D4 has been shown to be involved in several neurotransmission systems, including dopamine, serotonin, and GABA. Therefore, CACNA2D4 can be considered as a potential drug target for the treatment of psychiatric and neurological disorders associated with these neurotransmission systems.

For example, the alpha2delta 4 subunit has been shown to play a role in the regulation of dopamine release from the prefrontal cortical neurons. The prefrontal cortical neurons are involved in several higher-order cognitive processes, including decision-making, problem-solving, and planning. The dysfunction of the alpha2delta 4 subunit has been implicated in the development of symptoms of attention deficit hyperactivity disorder (ADHD), such as impulsivity, hyperactivity, and hyperactivity.

In addition to dopamine, the alpha2delta 4 subunit has also been shown to regulate serotonin and GABA release from the postsynaptic neurons. The postsynaptic neurons are involved in transmitting signals from the

Protein Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 4

Functions: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel

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