NEDD9: A Potential Drug Target for Neural Circuits, Inflammation and Cell Survival

Target Name: NEDD9

NCBI ID: G4739

NEDD9

NEDD9: A Potential Drug Target for Neural Circuits, Inflammation and Cell Survival

NEDD9 (NEDD9 variant 4) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and heart. It is a key regulator of the nervous system, and is involved in the development and maintenance of neural circuits. NEDD9 has also been implicated in a number of diseases, including neurodegenerative disorders, autoimmune diseases, and psychiatric conditions.

One of the key features of NEDD9 is its ability to interact with a variety of molecules, including GABA, a neurotransmitter that plays a critical role in the regulation of neural circuits. GABA is known for its ability to modulate the activity of other proteins, and NEDD9 has been shown to interact with GABA receptors in the brain. This interaction suggests that NEDD9 may be a drug target that could be targeted by small molecules.

In addition to its role in neural circuits, NEDD9 is also involved in the regulation of inflammation. Chronic inflammation has been implicated in a number of diseases, including neurodegenerative disorders, and NEDD9 has been shown to be involved in the regulation of inflammatory responses. This suggests that NEDD9 may be a biomarker for a variety of inflammatory disorders.

Another potential function of NEDD9 is its role in cell survival. NEDD9 has been shown to be involved in the regulation of cell survival and proliferation, and in the development of cancer. This suggests that NEDD9 may be a potential drug target for cancer therapies.

Overall, NEDD9 is a protein that has a number of potential functions, including its role in neural circuits, inflammation, and cell survival. Its interaction with GABA receptors and its involvement in the regulation of inflammatory responses make it a potential drug target for small molecules. Further research is needed to fully understand the role of NEDD9 in these processes and its potential as a drug target.

Protein Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 9

Functions: Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity)

The "NEDD9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NEDD9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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