NELL1: A Potential Drug Target for Neural Degenerative Diseases

Target Name: NELL1

NCBI ID: G4745

NELL1

NELL1: A Potential Drug Target for Neural Degenerative Diseases

NELL1 (Neural Growth Factor Receptor Type 1) is a protein that is expressed in various tissues of the body, including the nervous system. It is a member of the neurotrophic factor family, which includes proteins that promote the survival and growth of neural cells.

NELL1 has been shown to play a role in the development and maintenance of neural stem cells, which are cells that have the ability to develop into different types of neurons. These stem cells can give rise to a variety of neural cell types, including motor neurons , sensory neurons, and interneurons.

In addition to its role in stem cell development, NELL1 has also been shown to be involved in the regulation of neural circuits. It has been shown to interact with a variety of neural proteins, including the neurotransmitter GABA.

GABA is a chemical that is produced by neurons and that helps to regulate the activity of other neurons. It has been shown to play a role in the development and maintenance of neural circuits, and it is thought to play a key role in the function of NELL1.

One of the ways that NELL1 is involved in the regulation of neural circuits is through its interaction with GABA. This interaction is thought to be important for the regulation of neuronal excitability and the development of neural circuits.

In addition to its role in neural circuit regulation, NELL1 is also thought to be involved in the development and maintenance of the nervous system. It has been shown to play a role in the development of the nervous system in embryos, and it is thought to be involved in the regulation of neural stem cell proliferation.

Given its role in the regulation of neural circuits and its involvement in the development and maintenance of neural stem cells, NELL1 is a promising drug target. Studies have shown that inhibiting the activity of NELL1 has the potential to induce neuronal apoptosis in mouse, neuroprotective effects, and even to improve some of the cognitive functions.

In addition, there are some drugs that are currently in clinical trials that target NELL1, such as glycemic regulators (GLP-1 receptor agonist) and neuroprotective agents (BDNF-agonist), which may be useful in treating neurodegenerative diseases such as PA Kinson's disease, Alzheimer's disease, etc. have good prospects.

Overall, NELL1 is a protein that is expressed in various tissues of the body and is involved in the regulation of neural stem cell proliferation and the development of neural circuits. It is a promising drug target and may be useful in the treatment of neurodegenerative diseases.

Protein Name: Neural EGFL Like 1

Functions: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization

The "NELL1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NELL1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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