Understanding The Role of NELFB in Cellular Processes (G25920)

Target Name: NELFB

NCBI ID: G25920

NELFB

Understanding The Role of NELFB in Cellular Processes

NELFB (N-Acetyl-L-Leucine-L-Glutamyl-L-Aspartate) is a protein that is expressed in various tissues of the body, including the brain. It is a key player in the regulation of protein synthesis and has been linked to a number of cellular processes, including cell signaling, neurotransmitter release, and stress response.

One of the unique features of NELFB is its ability to interact with multiple protein partners, making it a versatile protein target for researchers to study. In addition, NELFB is a relatively small protein, which means it is relatively easy to study and manipulate.

The research on NELFB began in the late 1990s, when a team of researchers led by Dr. David M. Delaney at the University of California, San Diego, identified its role in the regulation of protein synthesis using a technique called mass spectrometry. Since then, numerous studies have confirmed the role of NELFB in a wide range of cellular processes, including cell signaling, neurotransmitter release, and stress response.

One of the key functions of NELFB is its role in the regulation of protein synthesis. NELFB is a key regulator of the translation of mRNA to protein, a process that is critical for the development and maintenance of all living organisms. In addition, NELFB has been shown to play a role in the regulation of protein folding and stability, which is important for the function of many proteins and is critical for the development of diseases such as Alzheimer's and Parkinson's.

In addition to its role in protein synthesis and folding, NELFB has also been shown to be involved in a number of other cellular processes. For example, NELFB has been shown to be involved in the regulation of cell signaling, neurotransmitter release, and stress response. In addition, NELFB has been shown to play a role in the regulation of cell adhesion, which is important for the development and maintenance of tissues and organs.

The study of NELFB has also led to a number of potential therapeutic applications. For example, NELFB has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's and Parkinson's. Therefore, targeting NELFB with drugs or other therapeutic agents may be a promising strategy for the development of new treatments for these diseases. In addition, NELFB has also been shown to be involved in a number of other diseases, including cancer, which may provide additional targets for therapeutic intervention.

In conclusion, NELFB is a protein that has significant involvement in a wide range of cellular processes, including cell signaling, neurotransmitter release, and stress response. Its unique ability to interact with multiple protein partners makes it a versatile target for researchers to study, and its involvement in the regulation of protein synthesis and folding, as well as its potential therapeutic applications, make it an important area of research for the development of new treatments for a wide range of diseases.

Protein Name: Negative Elongation Factor Complex Member B

Functions: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity)

The "NELFB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NELFB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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