NEMF: A Protein Essential for Protein Synthesis and Gene Expression

Target Name: NEMF

NCBI ID: G9147

NEMF

NEMF: A Protein Essential for Protein Synthesis and Gene Expression

NEMF (Ribosome quality control complex subunit NEMF isoform 1) is a protein that plays a critical role in ensuring the quality of proteins that are synthesized by ribosomes, which are the machines that translate mRNA into proteins. NEMF is a subunit of the Ribosome quality control complex, which is a complex of proteins that work together to ensure the accuracy and reliability of protein synthesis.

NEMF is a 21-kDa protein that is composed of two distinct isoforms: NEMF1 and NEMF2. NEMF1 is the most abundant isoform, and it is responsible for the initial quality control of incoming mRNAs. NEMF2 is a smaller isoform that is involved in the final quality control of translated proteins.

NEMF is important for protein synthesis because it helps to ensure that the amino acid sequence of proteins is correct and that the levels of certain amino acids are within acceptable limits. This is important for maintaining the structure and function of proteins, which are the cornerstone of all life on Earth.

One of the unique features of NEMF is its ability to interact with mRNAs in a process called \"cap-tran-poly(A) fusion.\" This process involves the fusion of the 3' end of an mRNA with the cap of a tRNA, resulting in a new tRNA that is correctly sized and has the correct sequence. NEMF is thought to play a key role in this process by helping to ensure that the mRNA is correctly processed and that the tRNA is correctly modified.

Another important function of NEMF is its role in \"exonation,\" which is the process of removing the exons (the parts of the mRNA that do not code for amino acids) from a pre-mRNA and creating a cDNA that is then translated into protein. NEMF is involved in this process by helping to ensure that the exons are correctly removed and that the resulting cDNA is correctly translated.

In addition to its role in protein synthesis, NEMF is also important for the regulation of gene expression. This is because NEMF is involved in the translation of mRNAs from the cytoplasm to the endoplasmic reticulum, where they can be processed and translated into proteins. NEMF is also thought to play a key role in the regulation of protein synthesis by interacting with various signaling pathways that regulate gene expression.

Despite its importance for protein synthesis and regulation, NEMF is not well understood. little is known about the specific functions of its subunits, and there is a lack of research on the mechanisms that govern its activity.

In conclusion, NEMF (Ribosome quality control complex subunit NEMF isoform 1) is a protein that plays a critical role in ensuring the quality of proteins that are synthesized by ribosomes. NEMF is a subunit of the Ribosome quality control complex, and it is involved in the initial and final quality control of incoming and translated mRNAs, as well as the regulation of gene expression. Despite its importance, NEMF is not well understood and there is a lack of research on its specific functions and mechanisms. Further studies are needed to gain a better understanding of the role of NEMF in protein synthesis and regulation.

Protein Name: Nuclear Export Mediator Factor

Functions: As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell. It is responsible both for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and the recruitment of the E3 ubiquitin-protein ligase LTN1 to the ribosome quality control complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875)

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