Understanding The Role of NEK2 in Cellular Processes (G4751)

Target Name: NEK2

NCBI ID: G4751

NEK2

Understanding The Role of NEK2 in Cellular Processes

NEK2 (Serine/threonine-protein kinase Nek2 (isoform 1)) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is involved in the regulation of cell proliferation, differentiation, and survival, and is considered a potential drug target or biomarker for several diseases.

The Nek2 gene was first identified in 1996, and it encodes a protein that consists of 218 amino acids. The protein has a unique structure, with a catalytic domain that is composed of a helix and a hyper active site, as well as a carboxylic acid tail. The catalytic domain is responsible for the protein's catalytic activity, and is involved in the catalytic mechanism of serine/threonine protein kinases.

Nek2 is a key regulator of cell proliferation and differentiation. It has been shown to play a role in the regulation of neural stem cell proliferation, and is required for the development and maintenance of neural stem cells. In addition, Nek2 has been shown to play a role in the regulation of cancer cell proliferation, and is often expressed in various types of cancer.

Nek2 has also been shown to be involved in the regulation of inflammation and immune responses. It has been shown to play a role in the regulation of T cell development and function, and is involved in the regulation of inflammation and immune responses. In addition, Nek2 has been shown to play a role in the regulation of fibrosis, and is involved in the regulation of extracellular matrix (ECM) formation.

Due to its involvement in multiple cellular processes, Nek2 has been identified as a potential drug target or biomarker for several diseases. For example, Nek2 has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In addition, Nek2 has been shown to be involved in the regulation of cancer cell growth and survival, making it a potential target for cancer therapies.

Nek2 has also been shown to be involved in the regulation of inflammation and immune responses, which makes it a potential target for therapies aimed at reducing inflammation and improving immune function. In addition, Nek2 has been shown to play a role in the regulation of fibrosis, which makes it a potential target for therapies aimed at reducing fibrosis and improving tissue repair.

In conclusion, NEK2 is a protein that is involved in multiple cellular processes and has been shown to play a role in the regulation of cell proliferation, differentiation, and survival. As a potential drug target or biomarker, NEK2 is a promising target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of NEK2 in cellular processes and its potential as a drug target or biomarker.

Protein Name: NIMA Related Kinase 2

Functions: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835)

The "NEK2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NEK2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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