GSTT2B: A Potential Drug Target Or Biomarker for Xenobiotics and Cellular Signaling Pathways

Target Name: GSTT2B

NCBI ID: G653689

GSTT2B

GSTT2B: A Potential Drug Target Or Biomarker for Xenobiotics and Cellular Signaling Pathways

GSTT2B (Glutathione S-transferase theta 2B, transcript variant 1) is a gene that encodes a protein known as GSTT2B, which is a member of the GST family of transmembrane proteins. GSTT2B is involved in the detoxification and metabolism of xenobiotics, such as drugs and environmental toxins, and is a potential drug target or biomarker for several diseases.

The GSTT2B gene was first identified in 2007 using DNA sequencing techniques. The gene encodes a protein that contains 116 amino acid residues and has a calculated molecular weight of 18.9 kDa. GSTT2B is expressed in most tissues of the body and is predominantly localized to the endoplasmic reticulum (ER) and the cytoplasm.

GSTT2B functions as a critical enzyme in the detoxification and metabolism of xenobiotics, such as drugs and environmental toxins, by participating in the detoxification pathway. Xenobiotics are often toxic to the body and can cause a wide range of adverse effects, including damage to the nervous system, the immune system, and the liver. Therefore, it is important to have enzymes that can efficiently detoxify and remove these substances from the body.

GSTT2B is involved in the detoxification of a wide range of xenobiotics, including drugs such as chemotherapy drugs, benzodiazepines, and arsenic. It has been shown to be a powerful detoxifier of arsenic, which is a toxic compound that can cause serious health problems if ingested in high concentrations. GSTT2B has also been shown to be involved in the detoxification of other xenobiotics, such as haliclorofluorocarbons (HCFCs) and perfluorinated compounds (PFCs), which are commonly found in environmental pollutants and have been linked to a wide range of health problems, including reproductive and developmental problems and cancer.

In addition to its role in drug detoxification, GSTT2B is also involved in the regulation of cellular signaling pathways. GSTT2B has been shown to be involved in the detoxification of environmental toxins, such as polychlorinated biphenyls (PCBs), which are commonly found in soil, water, and air and have been linked to a wide range of health problems, including reproductive and developmental problems.

GSTT2B is also involved in the regulation of cellular signaling pathways that are important for maintaining cellular homeostasis. GSTT2B has been shown to be involved in the detoxification of xenobiotics that can disrupt cellular homeostasis, such as reactive oxygen species (ROS), which are highly reactive molecules that can damage cellular components and contribute to a wide range of diseases, including cancer.

GSTT2B is a potential drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, GSTT2B has been shown to be involved in the development and progression of colon cancer, and may be a useful biomarker for this disease. In addition, GSTT2B has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and may be a useful biomarker for these conditions.

GSTT2B has also been shown to be involved in the development and progression of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and may be a useful biomarker for these conditions. In addition, GSTT2B has been shown to be involved in the regulation of cellular signaling pathways that are important for maintaining cellular homeostasis, and may be a useful target for drugs that

Protein Name: Glutathione S-transferase Theta 2B

Functions: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1417752). Has a sulfatase activity (PubMed:1417752)

The "GSTT2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GSTT2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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