KRTAP4-2: A Potential Drug Target and Biomarker (G85291)

Target Name: KRTAP4-2

NCBI ID: G85291

KRTAP4-2

KRTAP4-2: A Potential Drug Target and Biomarker

Keratin associated protein 4-2 (KRTAP4-2) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function make it an attractive target for researchers to investigate and develop new treatments.

KRTAP4-2 is a 22-kDa protein that is expressed in a variety of tissues, including brain, heart, skeletal muscles, and skin. It is composed of four domains: a N-terminus, a C-terminus, a middle transmembrane region , and an optional C-terminal tail. The N-terminus of KRTAP4-2 contains a unique farnesylated cysteine 鈥嬧?媟esidue, which is known to be a site for protein-protein interactions and may play a role in KRTAP4-2's function.

The C-terminus of KRTAP4-2 contains a cal hydrophobic amino acid residue, which may contribute to its stability and functions. The middle transmembrane region contains a variety of conserved amino acids that are involved in protein structure and function. The tail of KRTAP4-2 is composed of a unique glycine residue that may be involved in its stability and interactions with other proteins.

KRTAP4-2 has been shown to play a role in various physiological processes, including cell growth, differentiation, and inflammation. It has been shown to be involved in the regulation of cell proliferation, cell migration, and the development of cancer. It has also has been shown to be involved in the regulation of pain perception and neurotransmitter release, which may contribute to its potential as a drug target for pain management.

In addition to its potential as a drug target, KRTAP4-2 has also been identified as a potential biomarker for various diseases. Its expression has been shown to be elevated in a variety of tissues and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders . This suggests that KRTAP4-2 may be a useful biomarker for these diseases and could potentially serve as a target for new treatments.

The discovery and characterization of KRTAP4-2 as a potential drug target and biomarker has the potential to lead to new treatments for a variety of diseases. Further research is needed to fully understand its function and potential as a drug target and biomarker.

Protein Name: Keratin Associated Protein 4-2

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP4-2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP4-2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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