Golgin-3: A Potential Drug Target and Biomarker (G653125)

Target Name: GOLGA8K

NCBI ID: G653125

GOLGA8K

Golgin-3: A Potential Drug Target and Biomarker

The Golgi system is a network of organelles that functions as a scaffold to maintain the integrity of the endoplasmic reticulum (ER) in eukaryotic cells. It is a complex network of filaments, composed of several subfamilies, including the Golgin subfamily A, which is characterized by the presence of the protein Golgin-3 (also known as GLO-142).

Golgin-3 is a member of the Golgi cytoskeleton and is involved in the organization and stability of the ER. It plays a critical role in the regulation of ER retrieval, which is the process by which new endoplasmic reticulum-associated vesicles (ERVs) are formed and then targeted to specific cytoplasmic locations.

Recent studies have identified Golgin-3 as a potential drug target in the context of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The Golgin-3 protein has also been shown to be involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

One of the key advantages of Golgin-3 as a drug target is its expressedness in a wide range of human tissues and cells, including fetal tissues, cancer cells, and primary brain cells. This makes it a promising candidate for targeting mutations in the Golgin-3 gene that have been associated with various diseases.

Another advantage of Golgin-3 is its unique structure, which allows it to interact with various cellular signaling pathways. It has been shown to interact with several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. This interactivity makes it a potential target for small molecules that can modulate these signaling pathways and have therapeutic effects on various diseases.

In addition to its potential as a drug target, Golgin-3 has also been shown to be a potential biomarker for several diseases. Its expression has been shown to be associated with various diseases, including neurodegenerative diseases, cancer, and autoimmune disorders. This makes it a promising candidate for use as a diagnostic or therapeutic target in these diseases.

Golgin-3 has also been shown to play a critical role in the regulation of ER retrieval, which is the process by which new ERVs are formed and then targeted to specific cytoplasmic locations. Its involvement in this process makes it a potential target for drugs that can modulate ER retrieval and have therapeutic effects on various diseases.

In conclusion, Golgin-3 is a promising protein for drug targeting and biomarker research. Its unique structure and its involvement in multiple cellular signaling pathways make it a potential target for small molecules that can modulate its function. Further research is needed to fully understand its role in the regulation of ER retrieval and its potential as a drug target and biomarker.

Protein Name: Golgin A8 Family Member K

The "GOLGA8K Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOLGA8K comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets