Target Name: GOLGB1
NCBI ID: G2804
Review Report on GOLGB1 Target / Biomarker Content of Review Report on GOLGB1 Target / Biomarker
GOLGB1
Other Name(s): GOGB1_HUMAN | golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 | 372 kDa Golgi complex-associated protein | giantin | golgin B1, golgi integral membrane protein | Golgin B1, transcript variant 1 | golgi integral membrane protein 1 | Macrogolgin | Golgin B1, golgi integral membrane protein | golgin B1 | GOLGB1 variant 1 | GCP372 | Golgin subfamily B member 1 | Golgi integral membrane protein 1 | Golgin subfamily B member 1 (isoform 1) | Golgin B1, transcript variant 2 | Golgin subfamily B member 1 (isoform 2) | Golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 | GOLIM1 | Giantin | GCP | GOLGB1 variant 2

GOLGB1: A Protein Regulator of Neuronal Communication and Cellular Apoptosis

GOLGB1 (GOGB1_HUMAN), also known as G protein-coupled receptor GPCR, is a protein that is expressed in various tissues of the human body. It is a member of the G protein-coupled receptor family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling. GOLGB1 is a protein that is primarily expressed in the brain, and it is involved in a wide range of physiological processes, including brain development, neurotransmitter signaling, and cell survival.

GOLGB1 is a key regulator of neuronal communication, and it is involved in the intracellular signaling cascade that transmits signals from the neurotransmitter system to the cell surface. It is a critical receptor for many neurotransmitters, including dopamine, GABA, and endothelial cell-derived growth factor (VEGF). When these neurotransmitters bind to GOLGB1, they trigger a series of downstream signaling events that ultimately result in changes in cellular behavior and physiology.

One of the key functions of GOLGB1 is its role in modulating the activity of other proteins that are involved in neural circuits. GOLGB1 can interact with a wide range of proteins, including ion channels, tyrosine kinases, and serine/threonine kinases. These interactions can modulate the activity of these proteins, and ultimately affect the behavior of the cell.

GOLGB1 is also involved in the regulation of cellular apoptosis, which is the process by which cells undergo programmed cell death. During times of stress, such as exposure to toxins or radiation, GOLGB1 can help to prevent the excessive growth and damage that can occur. This is accomplished through the regulation of the execution of the apoptosis-associated protein (AP-1), which is a key mediator of cell death.

In addition to its role in modulating cellular behavior, GOLGB1 is also a potential drug target. The G protein-coupled receptor system is a rich source of drug targets, and GOLGB1 is no exception. There are many potential drugs that are currently in development that target GOLGB1 and its downstream signaling pathways. These drugs are designed to modulate the activity of GOLGB1 and to either enhance or inhibit its function.

One of the key challenges in developing drugs that target GOLGB1 is the complexity of its downstream signaling pathways. GOLGB1 is involved in many different signaling pathways, and it is difficult to predict how a particular drug will affect these pathways. This makes it difficult to identify the most effective and safe drugs that can be used to target GOLGB1.

Another challenge is the high degree of redundancy among the G protein-coupled receptor system. Many G protein-coupled receptors share similar functions and can be targeted by similar drugs. This makes it difficult to identify unique effects that may be associated with a particular drug.

Despite these challenges, there is significant progress that has been made in the development of drugs that target GOLGB1. Many of these drugs are in the early stages of development, and some have already been shown to be effective in preclinical studies. These drugs are being developed to treat a wide range of conditions, including neurological and psychiatric disorders, pain, and inflammation.

In conclusion, GOLGB1 is a protein that is involved in a wide range of physiological processes in the human body. It is a key regulator of neuronal communication and is involved in the intracellular signaling cascade that transmits signals from the neurotransmitter system to the cell surface. GOLGB1 is also involved in the regulation of cellular apoptosis and in the development of drugs that target it. Further research is needed to fully understand the function

Protein Name: Golgin B1

Functions: May participate in forming intercisternal cross-bridges of the Golgi complex

The "GOLGB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOLGB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

Golgi-associated retrograde protein (GARP) complex | GOLIM4 | GOLM1 | GOLM2 | GOLPH3 | GOLPH3L | GOLT1A | GOLT1B | GON4L | GON7 | GOPC | GORAB | GORASP1 | GORASP2 | GOSR1 | GOSR2 | GOT1 | GOT1-DT | GOT1L1 | GOT2 | GOT2P1 | GP1BA | GP1BB | GP2 | GP5 | GP6 | GP9 | GPA33 | GPAA1 | GPALPP1 | GPAM | GPANK1 | GPAT2 | GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156