Regulation of Intracellular Protein Levels By GOLGA6A: Potential Drug Target Or Biomarker

Target Name: GOLGA6A

NCBI ID: G342096

GOLGA6A

Regulation of Intracellular Protein Levels By GOLGA6A: Potential Drug Target Or Biomarker

The Golgi complex is a network of vesicles that forms the endoplasmic reticulum in eukaryotic cells. It is a highly specialized structure that functions to traffic proteins from the ER to the cell surface and to regulate the levels of intracellular proteins. The Golgi complex is composed of several families of proteins, including the A6 family, which is characterized by the presence of a characteristic hydrophobic domain and a transmembrane region. GOLGA6A (golgin A6) is a member of the A6 family and is a key component of the Golgi complex.

GOLGA6A is a protein that contains 115 amino acid residues and has a calculated molecular weight of 19.9 kDa. It is expressed in most tissues and cells of higher eukaryotes, including humans, and is predominantly localized to the endoplasmic reticulum. GOLGA6A is a soluble protein that can be expressed and purified from a variety of sources, including cell lines, tissues, and organs.

One of the key functions of GOLGA6A is its role in regulating the level of intracellular proteins. The Golgi complex is responsible for the retrieval of proteins from the ER and the delivery of them to the cytoplasm for subsequent degradation or storage. GOLGA6A is involved in this process by forming a complex with the transmembrane protein TGIP1 (transient GFP-iP1) and interacting with the cytoplasmic protein APT1 (alpha-type actinin). This interaction between GOLGA6A and APT1 allows for the regulation of the levels of intracellular proteins, including those involved in cell signaling and inflammation.

In addition to its role in regulating intracellular protein levels, GOLGA6A is also involved in the formation and maintenance of the Golgi complex itself. It is a key component of the network of vesicles that forms the endoplasmic reticulum and is involved in the regulation of the formation and fusion of these vesicles. GOLGA6A is also involved in the maintenance of the integrity of the endoplasmic reticulum, as seen in its role in the regulation of the level of protein synthesis in the ER.

GOLGA6A is also of interest as a potential drug target or biomarker. The Golgi complex is a highly specialized structure that is involved in the delivery of proteins from the ER to the cell surface, and targeting this system may provide new avenues for the development of therapeutic agents. Additionally, the regulation of intracellular protein levels by GOLGA6A may be involved in a variety of biological processes, including cell signaling and inflammation. The potential targets of this protein, including those involved in cell signaling pathways and inflammation, make GOLGA6A an attractive candidate for further research and development.

In conclusion, GOLGA6A is a key component of the Golgi complex and is involved in the regulation of intracellular protein levels and the formation and maintenance of the complex itself. Its role in these processes makes it an attractive candidate for further research and development as a potential drug target or biomarker. Further studies are needed to fully understand the functions of GOLGA6A and its potential as a therapeutic agent.

Protein Name: Golgin A6 Family Member A

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