GOLGA6L4: A Potential Drug Target and Biomarker (G643707)

Target Name: GOLGA6L4

NCBI ID: G643707

GOLGA6L4

GOLGA6L4: A Potential Drug Target and Biomarker

Golgi are a type of intracellular organization that plays a crucial role in the regulation of protein traffic and localization in eukaryotic cells. GOLGA6L4, a member of the putative golgin subfamily A, is a protein that localizes to the endoplasmic reticulum (ER) and is involved in the formation and stability of vesicles in the ER.

The ER is a specialized organ that plays a central role in the folding and processing of proteins. It is composed of a network of transmembrane protein structures that mediate the delivery of incoming proteins to the cytosol for further processing or degradation. The ER is also the site of several quality control mechanisms, including the glycylation of selector proteins, which can influence protein localization and interactions.

GOLGA6L4 is a 21-kDa protein that belongs to the family of adaptor proteins. It is characterized by a unique N-terminal region that contains a conserved nucleotide sequence known as \"N-Gln-F11\" (N-Gln-F11N/162). This sequence is highly conserved across different species and is involved in the formation of a conserved N-terminal tail that is critical for protein stability and localization.

GOLGA6L4 is expressed in most tissues and cells, and its localization to the ER is well established. It is highly expressed in the liver, heart, and pancreas, and has also been reported in a variety of other tissues, including the kidney, muscle, and placenta. GOLGA6L4 is also highly expressed in cancer tissues, which may be a potential biomarker for cancer progression.

In addition to its localization to the ER, GOLGA6L4 is involved in several cellular processes that are important for its function. For example, GOLGA6L4 is involved in the formation and stability of vesicles in the ER, which are critical for the delivery of incoming proteins to the cytosol for further processing or degradation. It is also involved in the regulation of protein interactions and localization, as well as in the regulation of cellular signaling pathways.

GOLGA6L4 has been identified as a potential drug target due to its involvement in several cellular processes that are important for its function. For example, GOLGA6L4 has been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and progression of many diseases, including cancer.

In addition to its involvement in the TGF-β pathway, GOLGA6L4 has also been shown to play a role in the regulation of other cellular processes, including the regulation of protein interactions and localization, as well as in the regulation of cellular signaling pathways. For example, GOLGA6L4 has been shown to interact with several other proteins, including the transcription factor, p53. This interaction between GOLGA6L4 and p53 may play a role in the regulation of cellular processes that are important for GOLGA6L4 function.

GOLGA6L4 has also been shown to be involved in the regulation of the cytosol-to-endoplasmic reticulum (C-to-ER) transport, which is a critical process for the delivery of incoming proteins to the ER for further processing or degradation. This process is regulated by several factors, including the transmembrane protein, TRPV4. The interaction between GOLGA6L4 and TRPV4 may play

Protein Name: Golgin A6 Family Like 4

The "GOLGA6L4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOLGA6L4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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