Target Name: GOT1
NCBI ID: G2805
Review Report on GOT1 Target / Biomarker Content of Review Report on GOT1 Target / Biomarker
GOT1
Other Name(s): AST | Cysteine transaminase, cytoplasmic | aspartate transaminase 1 | cysteine aminotransferase, cytoplasmic | glutamate oxaloacetate transaminase 1 | growth-inhibiting protein 18 | cCAT | transaminase A | cAspAT | AATC_HUMAN | Growth-inhibiting protein 18 | aspartate aminotransferase 1 | Glutamic-oxaloacetic transaminase 1 | testis secretory sperm-binding protein Li 196a | SGOT | Transaminase A | Aspartate aminotransferase, cytoplasmic | glutamic-oxaloacetic transaminase 1, soluble | Aspartate transaminase 1 | AST1 | Glutamic-oxaloacetic transaminase | Aspartate aminotransferase 1 | ASTQTL1 | cysteine transaminase, cytoplasmic | Glutamate oxaloacetate transaminase 1 | GIG18 | Cysteine aminotransferase, cytoplasmic | glutamic-oxaloacetic transaminase 1

Histamine Oxidase 1: A Promising Drug Target and Biomarker

GOT1 (histamine oxidase 1) is a gene that encodes for a protein known as histamine oxidase 1 (histamine oxidase 1, AtoE). Histamine oxidase 1 plays an important metabolic role in organisms and participates in a variety of physiological processes. During drug development, histamine oxidase 1 is often used as a drug target or biomarker. This article will elaborate on the application prospects of histamine oxidase 1 in drug research and development and explore its possible new drug targets.

1. The mechanism of action of histamine oxidase 1

Histamine oxidase 1 is an important enzyme whose catalytic activity plays a vital role in organisms. Histamine oxidase 1 mainly acts on histamine substances in the body. These substances are an important class of biologically active substances with strong biological activity and pharmacological effects. Histamine oxidase 1 can oxidize histamine substances into more biologically active products, thereby exerting its biological activity.

The mechanism of action of histamine oxidase 1 in organisms is very complex and involves multiple biological processes. First, histamine oxidase 1 is involved in the metabolism of histamine substances. Histamine oxidase 1 can catalyze the oxidation reaction of histamine substances to produce more biologically active products. These products have a wide range of biological activities in organisms, including bioactive peptides, neurotransmitters, growth factors, etc.

Secondly, histamine oxidase 1 also plays an important immune regulatory role in vivo. Histamine oxidase 1 is involved in regulating immune responses in organisms and participates in the differentiation and activation of immune cells through multiple pathways. Research shows that histamine oxidase 1 plays an important regulatory role in the immune system and can affect the function and activity of immune cells.

2. Application prospects of histamine oxidase 1 in drug research and development

Histamine oxidase 1 has broad application prospects in drug research and development. Since histamine oxidase 1 has a variety of important biological processes in organisms, it can become a target or biomarker for a variety of drugs. Several possible drug development targets related to histamine oxidase 1 will be introduced below.

1. Antihistamines

Antihistamines are a widely used class of drugs primarily used to treat allergic diseases. The mechanism of action of these drugs is closely related to the activity of histamine oxidase 1. Since histamine oxidase 1 is involved in the metabolic process of histamine substances, antihistamines can exert their pharmacological effects by inhibiting the activity of histamine oxidase 1. At present, a variety of antihistamine drugs have exerted their pharmacological effects by inhibiting the activity of histamine oxidase 1, such as loratadine, chlorpheniramine, etc.

2. Beta blockers

Beta-blockers are a widely used class of drugs, mainly used to treat cardiovascular diseases such as hypertension and angina. The mechanism of action of these drugs is closely related to the activity of histamine oxidase 1. Since histamine oxidase 1 is involved in the signaling process mediated by 尾-receptors, 尾-blockers can exert their pharmacological effects by inhibiting the activity of histamine oxidase 1. At present, a variety of 尾-blockers have exerted their pharmacological effects by inhibiting the activity of histamine oxidase 1, such as propranolol, atenol, etc.

3. Neurotransmitter receptor agonists

Neurotransmitter receptor agonists are a widely used class of drugs primarily used to treat neurological disorders. The mechanism of action of these drugs is closely related to the activity of histamine oxidase 1. Since histamine oxidase 1 is involved in the metabolic process of neurotransmitters, neurotransmitter receptor agonists can exert their pharmacological effects by stimulating the activity of histamine oxidase 1. At present, a variety of neurotransmitter receptor agonists have exerted their pharmacological effects by stimulating the activity of histamine oxidase 1, such as dopamine, norepinephrine, etc.

3. Research on biomarkers of histamine oxidase 1

Histamine oxidase 1 is very abundant in organisms and therefore can be studied as a potential biomarker. At present, various studies have confirmed that histamine oxidase 1 can be used as a biomarker for drug development and clinical trials.

1. Detection of histamine oxidase 1

at present,

Protein Name: Glutamic-oxaloacetic Transaminase 1

Functions: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456)

The "GOT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

GOT1-DT | GOT1L1 | GOT2 | GOT2P1 | GP1BA | GP1BB | GP2 | GP5 | GP6 | GP9 | GPA33 | GPAA1 | GPALPP1 | GPAM | GPANK1 | GPAT2 | GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183