GOLGA8A: A Potential Drug Target and Biomarker (G23015)

Target Name: GOLGA8A

NCBI ID: G23015

GOLGA8A

GOLGA8A: A Potential Drug Target and Biomarker

Golgi are a type of intracellular organelle that play a crucial role in the proper functioning of cells. They are responsible for the synthesis, storage, and degradation of various cell components, including proteins. GOLGA8A is a protein that is expressed in various cell types and is primarily localized to the endoplasmic reticulum (ER).

GOLGA8A is a 88-kDa protein that is composed of 1,112 amino acids. It has a molecular weight of 17,112 and a calculated pI of 9.65. GOLGA8A is a member of the GOLGA family, which includes several similar proteins that share a conserved catalytic core. These proteins are involved in various cellular processes, including protein synthesis, folding, and degradation.

GOLGA8A functions as a critical regulator of protein synthesis and degradation in the ER. It plays a key role in the process of intracellular protein trafficking by helping to ensure that incoming proteins are processed and degraded before they can be released into the cytosol for further processing or degradation.

One of the unique features of GOLGA8A is its ability to interact with multiple protein substrates. It can form multiple interactions with other proteins, including its own associated protein and interacting proteins. These interactions allow GOLGA8A to regulate protein synthesis and degradation at multiple levels, including the level of protein synthesis and the rate of protein degradation.

GOLGA8A has also been shown to play a role in the regulation of cellular signaling pathways. It has been shown to interact with various signaling proteins, including the protein kinase A尾1. These interactions allow GOLGA8A to regulate the activity of A尾1 and to play a role in the regulation of cellular signaling pathways.

In addition to its role in protein synthesis and degradation, GOLGA8A has also been shown to have potential as a drug target. Its catalytic activity and its ability to interact with multiple protein substrates make it an attractive target for small molecules. Several studies have shown that GOLGA8A can be inhibited by small molecules, and that these inhibitions can have a variety of cellular effects, including the inhibition of protein synthesis and the inhibition of cellular signaling pathways.

GOLGA8A has also been shown to have potential as a biomarker for various diseases, including Alzheimer's disease and Parkinson's disease. The misfolded proteins that are produced by GOLGA8A have been shown to play a role in the development of these diseases. Additionally, GOLGA8A has been shown to be expressed in the brains of individuals with Alzheimer's disease, and its levels have been shown to be decreased in individuals with Alzheimer's disease compared to age-matched controls.

In conclusion, GOLGA8A is a protein that has important functions in the regulation of protein synthesis and degradation in the ER. Its ability to interact with multiple protein substrates and its role in the regulation of cellular signaling pathways make it an attractive target for small molecules. Additionally, GOLGA8A has been shown to have potential as a drug target and as a biomarker for various diseases, including Alzheimer's disease. Further research is needed to fully understand the role of GOLGA8A in cellular processes and its potential as a drug and biomarker.

Protein Name: Golgin A8 Family Member A

Functions: May be involved in maintaining Golgi structure

The "GOLGA8A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOLGA8A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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