GOLGA8B: A Potential Drug Target and Biomarker (G440270)

Target Name: GOLGA8B

NCBI ID: G440270

GOLGA8B

GOLGA8B: A Potential Drug Target and Biomarker

GOLGA8B (GOG8B_HUMAN) is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, and kidneys. It is a member of the GOLGA family, which is known for its role in cell signaling and gene regulation. GOLGA8B is also known as GFP-J1, and it is a potential drug target and biomarker.

GOLGA8B is a 21-kDa protein that is expressed in the brain, heart, and kidneys. It is highly expressed in the brain, where it is found in the postsynaptic density of neurons, astrocytes, and microglia. GOLGA8B is also expressed in the heart, where it is found in the intercellular junctions of cardiac muscle cells. Additionally, GOLGA8B is expressed in the kidneys, where it is found in the podocytes.

GOLGA8B is a transcription factor that plays a role in gene regulation. It is a key regulator of the expression of many genes, including those involved in cell signaling and metabolism. GOLGA8B is known to regulate the activity of the transcription factor, NF-kappa-B, which is involved in inflammation and stress responses.

In addition to its role in gene regulation, GOLGA8B is also a potential drug target. GOLGA8B has been shown to interact with several drug targets, including the protein, PDGF-B, and the receptor, TRPV1. This suggests that GOLGA8B may be a useful target for new drugs that are designed to modulate these targets.

GOLGA8B may also be a biomarker for a variety of diseases. For example, GOLGA8B is downregulated in individuals with Alzheimer's disease, which is a degenerative brain disorder that is characterized by the progressive loss of brain cells. This suggests that GOLGA8B may be a potential therapeutic target for Alzheimer's disease.

In conclusion, GOLGA8B is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, and kidneys. It is a member of the GOLGA family and is known for its role in cell signaling and gene regulation. In addition to its role in gene regulation, GOLGA8B is also a potential drug target and biomarker. Further research is needed to fully understand the role of GOLGA8B in disease.

Protein Name: Golgin A8 Family Member B

Functions: May be involved in maintaining Golgi structure

The "GOLGA8B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOLGA8B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets