GOLGA8G: A Potential Drug Target and Biomarker (G283768)

Target Name: GOLGA8G

NCBI ID: G283768

GOLGA8G

Other Name(s): golgi autoantigen, golgin subfamily a, 8G | golgin A8 family member G | GOLGA8F | Golgin A8 family, member G

GOLGA8G: A Potential Drug Target and Biomarker

Golgi autoantigen (GAA) is a type of glycoprotein that is expressed in the Golgi apparatus, which is a specialized organelle responsible for the synthesis and processing of proteins in eukaryotic cells. GAAs are composed of four polypeptide chains: two heavy chains and two light chains. The heavy chains contain the majority of the protein's functional groups, including the active site, while the light chains provide the protein with its unique structure and stability.

Golgi autoantigens (GAs) are a subfamily of GAAs that are characterized by the presence of a specific conserved domain, known as the transmembrane domain (TMD). The TMD is a region of the protein that is involved in the formation of the protein's transmembrane domain and is responsible for its stability and interactions with other cellular components. GAs are involved in various cellular processes, including cell signaling, cell adhesion, and tissue repair.

One of the unique features of GAs is their ability to self-assemble into organized structures, such as the Golgi network. This self-assembly process is critical for the formation of GAs into functional subunits that can interact with other cellular components. The Golgi network is a complex system of filaments and vesicles that organize the Golgi autoantigens into distinct structures, including the endoplasmic reticulum (ER) and the cytosol.

GAAs have been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The high degree of homogeneity between GAs has made them an attractive target for drug development. GOLGA8G, a GAA that is expressed in various tissues and cells, has been identified as a potential drug target and biomarker.

GOLGA8G is a 12-kDa protein that is expressed in the liver, lung, kidney, and heart. It is characterized by the presence of a TMD and a N-terminus that is involved in the formation of the protein's transmembrane domain. The N-terminus of GOLGA8G contains a unique conserved region that is involved in the formation of the protein's N-terminus and is thought to play a role in its stability and interactions with other cellular components.

GOLGA8G has been shown to be involved in various cellular processes, including cell signaling, cell adhesion, and tissue repair. For example, GOLGA8G has been shown to be involved in the regulation of cell adhesion by interacting with the protein PDGFR-尾. Additionally, GOLGA8G has been shown to be involved in the regulation of cell signaling by interacting with the protein TCF-1.

GOLGA8G has also been shown to be involved in the regulation of tissue repair by interacting with the protein p53. The p53 is a well-known protein that is involved in the regulation of various cellular processes, including DNA damage repair and cell cycle control. GOLGA8G has been shown to be involved in the regulation of p53 activity by interacting with its N-terminus.

In addition to its involvement in cellular processes, GOLGA8G has also been shown to be involved in the regulation of cellular stress. GOLGA8G has been shown to be involved in the regulation of the stress response by interacting with the protein heat shock protein (Hsp)70.

GOLGA8G has also been shown to be involved in the regulation of inflammation by interacting with the protein NF-kappa-B. The NF-kappa-B is a well-known protein that is involved in the regulation of various cellular processes, including inflammation and cell signaling. GOLGA8G has been shown to be involved in the regulation of NF-kappa-B activity by interacting with its N-terminus.

GOLGA8G has also been shown to be involved in the regulation of the blood-brain barrier (BBB) by interacting with the protein

Protein Name: Golgin A8 Family Member G

The "GOLGA8G Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GOLGA8G comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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