IL-24 as A Potential Drug Target for Cancer and Autoimmune Disorders

Target Name: IL24

NCBI ID: G11009

IL24

IL-24 as A Potential Drug Target for Cancer and Autoimmune Disorders

IL-24, a cytokine that plays a crucial role in the regulation of immune responses and inflammation, has recently been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, autoimmune disorders, and chronic obstructive pulmonary disease (COPD).

IL-24 is a cytokine that is expressed in various tissues throughout the body, including the lungs, spleen, heart, kidneys, and lymphoid organs. It is a key regulator of T cell development and function, and has been shown to play a role in the regulation of immune responses, inflammation, and fibrosis.

One of the key functions of IL-24 is its ability to promote the activation and proliferation of T cells. T cells are a crucial part of the immune system, and are responsible for detecting and responding to foreign substances in the body. When T cells are activated, they undergo a process called clonal expansion, followed by differentiate into memory T cells and regulatory T cells. IL-24 has been shown to play a key role in the regulation of T cell development and function, and has been shown to promote the activation and proliferation of T cells.

IL-24 has also been shown to have a role in the regulation of inflammation. When the body is exposed to a foreign substance, such as bacteria or viruses, IL-24 is released in response to help stimulate an immune response. IL-24 has been shown to promote the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6. However, IL-24 has also been shown to have anti-inflammatory effects, as it can inhibit the production of pro-inflammatory cytokines.

In addition to its role in T cell development and function, IL-24 has also been shown to have a role in the regulation of fibrosis. Fibrosis is the process by which the body replaces damaged tissue with scar tissue, which can lead to a range of diseases, including cancer, heart disease, and COPD. IL-24 has been shown to promote the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6, which can contribute to the development and progression of fibrosis. However, IL-24 has also been shown to have anti-fibrosis effects, as it can inhibit the production of pro-inflammatory cytokines and promote the production of anti-inflammatory cytokines.

Due to its role in T cell development and function, IL-24 has recently been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, autoimmune disorders, and COPD. For example, some studies have shown that inhibiting the activity of IL-24 has the potential to treat cancer by suppressing the immune response and preventing the formation of cancerous tumors. Additionally, IL-24 has been shown to have the potential to treat autoimmune disorders, such as rheumatoid arthritis and lupus, by suppressing the production of pro-inflammatory cytokines and improving the function of immune cells.

In conclusion, IL-24 is a cytokine that plays a crucial role in the regulation of immune responses and inflammation. Its role in T cell development and function, as well as its anti-inflammatory and anti-fibrosis effects make it a promising candidate for the treatment of various diseases, including cancer, autoimmune disorders, and COPD. Further research is needed to fully understand the potential mechanisms of IL-24 and its potential as a drug target or biomarker.

Protein Name: Interleukin 24

Functions: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I intereferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity)

The "IL24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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