IL-36: Cytokine with Potential as Drug Target and Biomarker (G27177)

Target Name: IL36B

NCBI ID: G27177

IL36B

IL-36: Cytokine with Potential as Drug Target and Biomarker

Interleukin 36 (IL-36), also known as IL-36尾, is a cytokine that plays a crucial role in the regulation of immune responses and tissue homeostasis. It is a member of the interleukin family, which includesIL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, and IL-12, and is expressed in a variety of tissues throughout the body, including immune organs, tissues, and cells.

IL-36 is a cytokine that is involved in the regulation of immune responses, as well as tissue homeostasis. It is a key regulator of T cell development and function, and has been shown to play a role in the regulation of inflammation, autoimmunity, and cancer.

IL-36 has also been shown to be involved in the regulation of stem cell proliferation and differentiation. It has been shown to promote the proliferation of stem cells, and to play a role in the regulation of stem cell self-renewal and differentiation.

IL-36 has also been shown to be involved in the regulation of tissue repair and regeneration. It has been shown to promote the growth and differentiation of progenitor cells, and to play a role in the regulation of tissue repair and regeneration following injury or disease.

IL-36 has also been shown to be involved in the regulation of metabolism and energy homeostasis. It has been shown to play a role in the regulation of energy metabolism, and to be involved in the regulation of muscle mass and body weight.

Despite the many important functions of IL-36, it is still a relatively well-unknown cytokine. There is ongoing research into the potential uses of IL-36 as a drug target and biomarker, with several studies showing promise in this area.

One of the main goals of research into IL-36 is to understand its role in the regulation of immune responses and tissue homeostasis. This is an important area of research, as understanding the functions of IL-36 and its potential as a drug target could lead to the development of new treatments for a variety of diseases.

Another important area of research into IL-36 is its potential as a biomarker. IL-36 has been shown to be involved in the regulation of a wide range of physiological processes, including immune responses, tissue homeostasis, and metabolism. As such, it has the potential to be used as a biomarker for a variety of diseases, including cancer, autoimmunity, and metabolism.

IL-36 has also been shown to be involved in the regulation of stem cell proliferation and differentiation, which is an area of research that is of great interest to scientists. Stem cells have the potential to be used to treat a wide range of diseases, including cancer, and researchers are working to understand the role of IL-36 in the regulation of stem cell proliferation and differentiation.

In addition to its potential as a drug target and biomarker, IL-36 is also of interest to researchers due to its unique structure and biology. IL-36 is a cytokine that is expressed in a variety of tissues throughout the body, and its structure and biology are not well understood. As such, researchers are working to understand the role of IL-36 in the regulation of immune responses and tissue homeostasis, as well as its potential as a drug target and biomarker.

Overall, IL-36 is a cytokine that has a wide range of potential functions, both as a drug target and as a biomarker. Further research is needed to fully understand its role in the regulation of immune responses and tissue homeostasis, and to explore its potential as a treatment for a variety of diseases.

Protein Name: Interleukin 36 Beta

Functions: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6

The "IL36B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL36B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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