IL-6R: Key Regulator of Immune System (G3570)

Target Name: IL6R

NCBI ID: G3570

IL6R

IL-6R: Key Regulator of Immune System

IL-6R (Interleukin 6 receptor), transcript variant 2, is a protein that plays a crucial role in the immune system. It is a cytokine that is produced by various immune cells in response to the presence of foreign particles in the body. IL-6R is a key regulator of immune responses and has been implicated in a number of diseases, including cancer, autoimmune disorders, and obesity.

IL-6R is a transmembrane protein that is expressed in various tissues throughout the body, including the immune cells, tissues, and organs. It is a member of the interleukin 6 receptor family, which is a subclass of the cytokine receptor superfamily. The interleukin 6 receptor family includes several different transcript variants, including IL-6R, which is the most well-studied.

IL-6R is involved in the regulation of immune responses and has been implicated in a number of diseases. One of the most well-known functions of IL-6R is its role in cancer. IL-6R has been shown to promote the growth and survival of various types of cancer cells, including breast, ovarian, and prostate cancer. It is also involved in the regulation of immune cell function and has been implicated in the development of autoimmune disorders, such as rheumatoid arthritis and type 1 diabetes.

IL-6R has also been shown to be involved in the regulation of obesity. It has been shown to contribute to the development and maintenance of obesity by promoting the production of adipose tissue and increasing the sensitivity of tissues to insulin.

Despite the potential implications of IL-6R in a number of diseases, research into its role in these processes is still in its infancy. There are only a few studies that have directly addressed the functions of IL-6R in these areas, and more research is needed to fully understand its role.

In addition to its potential as a drug target, IL-6R is also a potential biomarker for several diseases. Its role in cancer and autoimmune disorders makes it an attractive candidate for targeting with small molecules or antibodies. IL-6R may also be used as a biomarker for tracking the effectiveness of anti-obesity treatments.

In conclusion, IL-6R is a protein that plays a crucial role in the immune system and has been implicated in a number of diseases. Its functions in cancer, autoimmune disorders, and obesity make it an attractive candidate for targeting with small molecules or antibodies. Further research is needed to fully understand its role and potential as a biomarker.

Protein Name: Interleukin 6 Receptor

Functions: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, PubMed:31235509). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)

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