IL-37 Protein: Regulating Immune Response and Inflammation (G27178)

Target Name: IL37

NCBI ID: G27178

IL37

IL-37 Protein: Regulating Immune Response and Inflammation

The IL-37 protein is a cytokine that plays a crucial role in the regulation of immune responses and inflammation. It is a member of the interleukin family, which includes proteins that belong to different subfamilies, such as IL-1, IL-2, and IL-12. The IL-37 protein is expressed in a variety of tissues and cells in the body, including the immune system, where it is involved in the regulation of the immune response.

IL-37 is a cytokine that is derived from the fusion of the alpha chain of the interleukin-1 receptor with the beta chain of the interleukin-1 receptor. This fusion protein is then processed in the cell to produce the mature IL-37 protein. The IL-37 protein is made up of 110 amino acids and has a molecular weight of 17 kDa.

The IL-37 protein is involved in the regulation of the immune response by promoting the production of pro-inflammatory cytokines. These cytokines, such as TNF-alpha, IL-1, and IL-6, are important for the recruitment of immune cells to the site of an infection or inflammation and for the regulation of the inflammatory response. The production of these cytokines is tightly regulated by the IL-37 protein, which is able to inhibit the activity of several transcription factors that are involved in the production of these cytokines.

The IL-37 protein is also involved in the regulation of cell growth and differentiation. It has been shown to promote the growth and survival of immune cells, such as natural killer cells and T-cells, and to regulate the production of new immune cells in the bone marrow. The IL-37 protein is also involved in the regulation of cell death, as it has been shown to induce the apoptosis (programmed cell death) of certain immune cells when they are no longer needed.

The IL-37 protein is a potential drug target for several diseases, including cancer, as it has been shown to promote the growth and survival of cancer cells. It is also involved in the regulation of inflammation, which is a leading cause of many diseases, including heart disease, diabetes, and autoimmune disorders. As a result, the IL-37 protein is a promising target for the development of new treatments for a variety of diseases.

In conclusion, the IL-37 protein is a key player in the regulation of the immune response and inflammation. It is involved in the production of pro-inflammatory cytokines and in the regulation of cell growth and differentiation. The IL-37 protein is a potential drug target for several diseases and has been shown to promote the growth and survival of cancer cells. Further research is needed to fully understand the role of the IL-37 protein in the regulation of the immune response and inflammation, and to develop effective treatments for a variety of diseases.

Protein Name: Interleukin 37

Functions: Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation

The "IL37 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL37 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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