TMEM134: A Potential Drug Target and Biomarker for neurological Disorders

Target Name: TMEM134

NCBI ID: G80194

TMEM134

TMEM134: A Potential Drug Target and Biomarker for neurological Disorders

TMEM134 (Transmembrane Protein 134) is a gene that encodes a protein located at the cell membrane, which is involved in various cellular processes. The study of TMEM134 has significant implications for our understanding of neurological disorders, as it may serve as a potential drug target or biomarker. In this article, we will explore the structure, function, and potential therapeutic applications of TMEM134.

Structure and Function

TMEM134 is a 124- amino acid protein that is expressed in various tissues, including brain, heart, and pancreas. The protein has a unique structure, as it consists of a transmembrane region and a cytoplasmic region. The transmembrane region is made up of four尾-helices, each of which is composed of 12 amino acids. The cytoplasmic region contains a variable region that includes several potential drug binding sites.

TMEM134 is involved in various cellular processes, including cell signaling, cell adhesion, and intracellular signaling. It has been shown to play a role in the regulation of ion channels, which are critical for the flow of electrical current through the cell membrane. TMEM134 has also been shown to interact with various signaling molecules, including TGF-β1, a well-known protein that plays a role in cell signaling and growth.

Potential Therapeutic Applications

The potential therapeutic applications of TMEM134 are vast and varied. As a drug target, TMEM134 may be targeted with small molecules or antibodies to modulate its activity and improve the treatment of neurological disorders. For example, TMEM134 has been shown to play a role in the regulation of neuronal excitability, which may make it a potential target for treating neuroexcitable disorders such as epilepsy and Parkinson's disease. Additionally, TMEM134 has been shown to be involved in the regulation of ion channels, which may make it a potential target for treating disorders related to ion channels, such as heart failure and hypokalemia.

As a biomarker, TMEM134 may be used to diagnose and monitor the progression of neurological disorders. For example, TMEM134 has been shown to be expressed in the brains of patients with Alzheimer's disease, and its levels have been found to be decreased in the brains of individuals with Parkinson's disease. This suggests that TMEM134 may be a useful biomarker for the diagnosis and monitoring of these disorders.

Conclusion

TMEM134 is a protein that is expressed in various tissues and is involved in various cellular processes. Its unique structure and function make it an attractive target for drug development, as well as a potential biomarker for the diagnosis and monitoring of neurological disorders. Further research is needed to fully understand the role of TMEM134 in cellular processes and its potential therapeutic applications.

Protein Name: Transmembrane Protein 134

The "TMEM134 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM134 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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