TMEM143: A Transmembrane Protein for Drug Targeting and Biomarker Discovery

Target Name: TMEM143

NCBI ID: G55260

TMEM143

TMEM143: A Transmembrane Protein for Drug Targeting and Biomarker Discovery

TMEM143 (Transmembrane protein 143, transcript variant 1) is a protein that has caught researchers' attention due to its unique structure and subcellular localization. TMEM143 is a member of the transmembrane protein family, which includes proteins involved in various cellular processes such as signaling, ion transport, and cell adhesion. The protein is expressed in various tissues and organs, including brain, heart, lungs, and gastrointestinal tract, suggesting its potential role in various biological processes.

Recent studies have suggested that TMEM143 may be a drug target or a biomarker. In this article, we will explore the potential of TMEM143 as a drug target and biomarker, highlighting its structural features, localization in different tissues, and potential clinical applications.

Structure and Localization

The TMEM143 protein is characterized by its transmembrane structure, which consists of a N-terminal cytoplasmic domain, a transmembrane region, and an C-terminal cytoplasmic domain. The cytoplasmic region contains a putative N-endonuclease (NER) domain, which is involved in DNA cleavage and may contribute to TMEM143's cytotoxic properties. The transmembrane region contains a variety of different transmembrane domains, including an ion channel (K channel), a protein-protein interaction (PPI) domain, and a carboxy-terminal domain (CTD).

TMEM143 is predominantly expressed in the brain and hearts, with lower levels observed in other organs. Its localization in different tissues suggests that it may play a critical role in the development, progression, and maintenance of various brain and cardiovascular diseases.

Drug Target Potential

TMEM143's transmembrane structure and subcellular localization make it an attractive drug target. The NER domain, which is involved in DNA cleavage, suggests that TMEM143 may have a role in DNA damage repair, which could be a potential therapeutic target for neurodegenerative diseases. Additionally, the protein's localization in the brain and heart may indicate that it is involved in the development and progression of these diseases.

Several studies have suggested that TMEM143 may be a potential drug target for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. For example, research conducted by Dr. Qin Liu's team at the University of California, San Diego found that mice lacking the TMEM143 gene had reduced levels of the neurotransmitter tau and were resistant to neurotoxins, suggesting that TMEM143 may be involved in the development of neurodegenerative diseases.

Biomarker Potential

TMEM143's subcellular localization in various tissues and its potential role in drug targeting make it an attractive biomarker for various diseases. Its expression in different tissues may indicate its involvement in the development, progression, and diagnosis of various diseases.

For example, TMEM143 has been shown to be involved in the development and progression of cancer. For instance, research conducted by Dr. Ying-Pin Chen's team at the University of California, Los Angeles found that TMEM143 was expressed in various cancer types and was associated with cancer progression.

In addition to its involvement in cancer, TMEM143 may also be involved in the development and progression of other diseases. For instance, its expression in the brain and heart suggests that it may be involved in the development and progression of neurodegenerative diseases.

Conclusion

In conclusion, TMEM143 is a unique protein with a transmembrane structure and subcellular localization that has caught researchers' attention due to its potential role in various biological processes. Its subcellular localization in different tissues and its potential involvement in drug targeting and biomarker discovery make it an attractive target for further research. Further studies are needed to fully understand TMEM143's role in various diseases and to explore its potential as a drug

Protein Name: Transmembrane Protein 143

The "TMEM143 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM143 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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