TMEM144: A Transmembrane Protein Target for Drug Development and Disease Treatment

Target Name: TMEM144

NCBI ID: G55314

TMEM144

Other Name(s): Transmembrane protein 144 | transmembrane protein 144 | TM144_HUMAN

TMEM144: A Transmembrane Protein Target for Drug Development and Disease Treatment

TMEM144 is a transmembrane protein that is expressed in various tissues and organs, including the brain, heart, kidneys, and intestine. Its primary function is to regulate the movement of ions and molecules across the membrane. However, recent studies have found that TMEM144 is also involved in various signaling pathways and has been implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This has led to its potential as a drug target or biomarker. In this article, we will explore the biology and potential therapeutic applications of TMEM144.

Biogenesis and Localization

TMEM144 is a member of the transmembrane protein (TM) family, which includes several other well-known proteins, including TMEM167, TMEM182, and TMEM214. These proteins are characterized by their ability to span the membrane and interact with various intracellular signaling pathways. TMEM144 is similar to its splice variants, TMEM167 and TMEM182, in that it contains a transmembrane region and cytoplasmic tail, as well as an N-terminus that is involved in protein-protein interactions and a C-terminus that is involved in intracellular signaling pathways.

TMEM144 is primarily expressed in the brain and other organs, and its localization to specific cellular compartments is well understood. TMEM144 is predominantly expressed in the endoplasmic reticulum (ER), a protein-protein interaction (PPI) network that plays a crucial role in the regulation of intracellular signaling pathways. It is also expressed in the cytoplasm and has been shown to interact with various intracellular signaling proteins, including serine/thiosephosphate-protein kinase (S/TPK), which is involved in the regulation of cell signaling pathways.

Function and Significance

TMEM144 is involved in several signaling pathways that are crucial for the proper functioning of various organs and tissues. One of its most significant functions is its role in the regulation of ion and molecule movement across the endplastmembrane, which is a critical aspect of the regulation of intracellular signaling pathways. TMEM144 is known to interact with various endplastmembrane proteins, including the ion channel protein, K+ channel, and Ca2+ channel proteins. These interactions play a crucial role in the regulation of ion flux and in the maintenance of the resting membrane potential of the endplastmembrane.

In addition to its role in ion and molecule regulation, TMEM144 is also involved in the regulation of cellular signaling pathways. Its localization to the ER and its interaction with intracellular signaling proteins, such as S/TPK, play a crucial role in the regulation of cellular signaling pathways, including cell growth, apoptosis, and inflammation.

TMEM144 has also been implicated in the development and progression of several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its involvement in these diseases has led to its potential as a drug target or biomarker. For example, recent studies have shown that TMEM144 is involved in the regulation of the growth and survival of cancer cells, and that its inhibition may be a promising strategy for cancer treatment.

In addition to its potential therapeutic applications, TMEM144 is also a potential biomarker for several diseases. Its localization to the ER and its interaction with intracellular signaling proteins make it an attractive target for diagnostic tests for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Its involvement in the regulation of ion and molecule movement also makes it an attractive target for diagnostic tests for

Protein Name: Transmembrane Protein 144

The "TMEM144 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM144 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets