Target Name: WDR43
NCBI ID: G23160
Review Report on WDR43 Target / Biomarker Content of Review Report on WDR43 Target / Biomarker
WDR43
Other Name(s): WD repeat domain 43 | KIAA0007 | NET12 | WDR43_HUMAN | U3 small nucleolar RNA-associated protein 5 homolog | UTP5 | WD repeat-containing protein 43 | UTP5, small subunit (SSU) processome component, homolog

Understanding WDR43: A Potential Drug Target and Biomarker

WDR43 (Wavelet-derived region 43) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a 22-kDa protein that is expressed in various tissues and cell types, including brain, heart, and liver. The function of WDR43 is not well understood, but it is known to be involved in several cellular processes, including cell adhesion, migration, and transcriptional regulation.

Drug Target Potential

WDR43 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. The WDR43 protein is composed of 1,942 amino acids and has a calculated molecular mass of 21.9 kDa. It is characterized by a highly conserved N-terminus, a unique T-loop region, and a C-terminus that is rich in acidic and basic residues.

The WDR43 protein is involved in several cellular processes that are crucial for its function. One of the most significant functions of WDR43 is its role in cell adhesion. WDR43 has been shown to be involved in the formation of tight junctions, which are critical for maintaining tissue structure and function. tight junctions are specialized junctions that are responsible for maintaining the integrity of the intercellular space and for regulating the flow of molecules between cells.

Another function of WDR43 is its role in cell migration. WDR43 has been shown to be involved in the regulation of cell migration, which is a critical process for the development and maintenance of tissues and organs. It is known to play a role in the formation of migration gradients, which are critical for the migration of cells along the gradient.

In addition to its role in cell adhesion and migration, WDR43 is also involved in transcriptional regulation. It has been shown to play a role in the regulation of gene expression, specifically in the regulation of cell-specific gene expression. This is important for the development and maintenance of tissues and organs, as well as for the regulation of cellular processes.

Biomarker Potential

WDR43 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. This is because it is involved in several cellular processes that are disrupted in these diseases, providing a potential target for the development of new therapies.

For example, WDR43 has been shown to be involved in the regulation of cancer cell growth and progression. It has been shown to play a role in the regulation of cell cycle progression, which is critical for the development and maintenance of cancer cells. In addition, WDR43 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed in tumors.

WDR43 has also been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells, which is thought to be due to the regulation of several genes, including WDR43.

In addition, WDR43 has also been shown to be involved in the regulation of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. These conditions are characterized by the production of antibodies that target the body's own tissues, leading to inflammation and damage.

Conclusion

In conclusion, WDR43 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. Its unique structure and its involvement in several cellular processes make it an attractive target for the development of new therapies. Further research is needed to fully understand the function of WDR43 and its potential as a drug target and biomarker.

Protein Name: WD Repeat Domain 43

Functions: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity)

The "WDR43 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR43 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

WDR44 | WDR45 | WDR45B | WDR46 | WDR47 | WDR48 | WDR49 | WDR5 | WDR53 | WDR54 | WDR55 | WDR59 | WDR5B | WDR6 | WDR62 | WDR64 | WDR7 | WDR70 | WDR72 | WDR73 | WDR74 | WDR75 | WDR76 | WDR77 | WDR81 | WDR82 | WDR82P1 | WDR83 | WDR83OS | WDR86 | WDR86-AS1 | WDR87 | WDR88 | WDR89 | WDR90 | WDR91 | WDR93 | WDR97 | WDSUB1 | WDTC1 | WEE1 | WEE2 | WEE2-AS1 | WFDC1 | WFDC10A | WFDC10B | WFDC11 | WFDC12 | WFDC13 | WFDC2 | WFDC21P | WFDC3 | WFDC5 | WFDC6 | WFDC8 | WFDC9 | WFIKKN1 | WFIKKN2 | WFS1 | WHAMM | WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73 | WRN | WRNIP1