RNA-Nucleases: Enzymes Involved in RNA Degradation (G246243)
RNA-Nucleases: Enzymes Involved in RNA Degradation
RNA-Nucleases (RNases) are a group of enzymes that are involved in the process of RNA degradation. These enzymes act on RNA molecules and break them down into smaller pieces, which can then be used by the cell for various purposes. One of the RNA-Nucleases is RNASEH1 (Ribonuclease H1 isoform 2).
RNASEH1 is an enzyme that is expressed in various cell types, including the liver, spleen, and pancreas. It is a 23 kDa protein that consists of 126 amino acid residues. The protein has a molecular weight of 17.5 kDa and a calculated pI of 6.8.
RNASEH1 is involved in the degradation of various RNA types, including microRNA (miRNA), double-stranded RNA (dsRNA), and small interfering RNA (siRNA). These RNA molecules are produced by the cell and have various functions, such as regulating gene expression, DNA replication, and post-transcriptional modification.
RNASEH1 is a potent enzyme that is involved in the degradation of many different RNA types. One of its most well-known functions is its role in the degradation of miRNA. MiRNA is a small non-coding RNA molecule that plays a crucial role in post -transcriptional gene regulation by silencing coding RNAs. RNASEH1 is known to cleave miRNA duplexes, which are formed by the combination of a miRNA molecule and a complementary RNA molecule.
In addition to its role in miRNA degradation, RNASEH1 is also involved in the degradation of other RNA types. For example, it has been shown to cleave double-stranded RNA (dsRNA) molecules, which are often involved in gene regulation. The degradation of dsRNA by RNASEH1 has been shown to play a role in the regulation of gene expression and can lead to the activation of RNA-dependent RNA polymerases (RDORs).
RNASEH1 is also involved in the degradation of siRNA, a type of RNA molecule that can be used to knockdown (inhibit) gene expression in the cell. SiRNA is produced by the cell and has been shown to play a crucial role in the regulation of gene expression and can act as a negative regulator of gene expression. RNASEH1 has been shown to cleave siRNA duplexes, which are formed by the combination of a siRNA molecule and a complementary RNA molecule.
The cleavage of RNA by RNASEH1 is a critical process that is involved in the regulation of gene expression. It is well-known that RNA-Nucleases play a crucial role in the degradation of RNA molecules that are involved in gene expression. The activity of RNASEH1 and other RNA-Nucleases can be inhibited by various methods, such as using RNA interference (RNA-i) techniques or by using small interfering RNA (siRNA) to silence gene expression.
In conclusion, RNASEH1 is an important enzyme that is involved in the degradation of various RNA types. One of its most well-known functions is its role in the degradation of miRNA, but it also has been shown to be involved in the degradation of other RNA types, such as double-stranded RNA (dsRNA) and small interfering RNA (siRNA). The cleavage of RNA by RNASEH1 is a critical process that is involved in the regulation of gene expression and can be inhibited by various methods. Therefore, RNASEH1 may be a promising drug target or biomarker for various diseases.
Protein Name: Ribonuclease H1
Functions: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224)
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More Common Targets
RNASEH1-DT | RNASEH2A | RNASEH2B | RNASEH2B-AS1 | RNASEH2C | RNASEH2CP1 | RNASEK | RNASEL | RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43
