Trav38-2DV8: A Potential Drug Target and Biomarker (G28643)

Target Name: TRAV38-2DV8

NCBI ID: G28643

TRAV38-2DV8

Other Name(s): TRAV382DV8 | hADV38S2 | T cell receptor alpha variable 38-2/delta variable 8 | TCRAV14S1

Trav38-2DV8: A Potential Drug Target and Biomarker

Trav38-2DV8 is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the Travis family of proteins, which are known for their role in cell signaling and inflammation. The function and regulation of travis38-2DV8 is not well understood, but its potential role in diseases such as diabetes, hypertension, and neurodegenerative disorders are of interest.

Potential Drug Target

One of the main functions of travis38-2DV8 is its role in cell signaling. It is involved in the regulation of cell adhesion, migration, and survival, and is a potential drug target for several diseases. Travis38-2DV8 has been shown to play a role in the development and progression of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

In addition, travis38-2DV8 has also been shown to be involved in the regulation of inflammation and immune response. It has been shown to play a role in the regulation of T cell function and the production of inflammatory cytokines. This suggests that travis38-2DV8 may be a potential drug target for diseases that are characterized by inflammation and immune dysfunction, such as rheumatoid arthritis and inflammatory bowel disease.

Potential Biomarker

Another potential function of travis38-2DV8 is its role as a biomarker for several diseases. The travis38-2DV8 protein has been shown to be expressed in a variety of tissues and cells, including blood vessels, nerve cells, and brain cells. This suggests that it may be a potential biomarker for several diseases, including neurodegenerative disorders, cardiovascular disease, and diabetes.

In addition, travis38-2DV8 has also been shown to be involved in the regulation of cell signaling and protein synthesis, which suggests that it may be a potential biomarker for diseases that are characterized by protein synthesis and cell signaling dysfunction, such as cancer.

Conclusion

Trav38-2DV8 is a protein that is expressed in various tissues of the human body, and its function and regulation are not well understood. However, its potential role in cell signaling and inflammation, as well as its potential as a biomarker for several diseases, make it an interesting target for research and development of new therapies. Further studies are needed to fully understand the function and regulation of travis38-2DV8, and to determine its potential as a drug target and biomarker.

Protein Name: T Cell Receptor Alpha Variable 38-2/delta Variable 8

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRAV38-2DV8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAV38-2DV8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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