NDUFA3: A Protein Regulating Serotonin Production (G4696)

Target Name: NDUFA3

NCBI ID: G4696

NDUFA3

NDUFA3: A Protein Regulating Serotonin Production

NDUFA3 (N-Acetyl-L-Tryptophan-2-yl-2-methylpiperidone), also known as NDUA3-HUMAN, is a protein that is expressed in various tissues of the human body, including the brain, muscle, and liver. It is a key regulator of the production of serotonin, a neurotransmitter that plays a crucial role in mood, appetite, and other physiological processes.

NDUFA3 is composed of four distinct subunits, each of which has distinct functions in cell signaling. The first subunit, NDUFA3-A, is a 21-kDa protein that is predominantly expressed in the brain. It is involved in the production of various neurotransmitters, including serotonin, dopamine, and GABA. The second subunit, NDUFA3-B, is a 17-kDa protein that is predominantly expressed in muscle. It is involved in the production of muscle relaxants, which can improve muscle function and reduce muscle tension. The third subunit, NDUFA3-C, is a 12-kDa protein that is predominantly expressed in the liver. It is involved in the production of various compounds, including tryptophan, which is a key precursor of serotonin. The fourth subunit, NDUFA3-D, is a 6-kDa protein that is primarily expressed in the lungs. It is involved in the production of various lung surfactants, which help to reduce surface tension and improve lung expansion.

The unique function of NDUFA3 is its ability to regulate the production of serotonin from tryptophan, which is the most abundant amino acid in the body. Serotonin is involved in the regulation of various physiological processes, including mood, appetite, and sleep. It is also involved in the transmission of pain signals from the body to the brain.

NDUFA3 plays a crucial role in the production of serotonin from tryptophan. It is a key regulator of the conversion of tryptophan to serotonin in the brain. Studies have shown that individuals with genetic variants in theNDUFA3 gene are more likely to have symptoms of depression and anxiety, which may be related to their ability to regulate serotonin production.

In addition to its role in serotonin production, NDUFA3 is also involved in the regulation of other neurotransmitters, including dopamine and GABA. It is a key regulator of the uptake and release of dopamine from its storage sites in the brain, and it is involved in the production of GABA, which is a inhibitory neurotransmitter.

The potential therapeutic applications of NDUFA3 are vast. As a drug target, it could be used to treat a variety of psychiatric and neurological disorders, including depression, anxiety, and psychosis. It could also be used to treat other conditions, such as chronic pain, insomnia, and neurodegenerative diseases.

In addition to its potential therapeutic applications, NDUFA3 is also a valuable biomarker for various psychiatric and neurological disorders. Its expression is often reduced in individuals with psychiatric and neurological disorders, which could be used as a diagnostic marker for these conditions.

Overall, NDUFA3 is a protein that plays a crucial role in the regulation of serotonin production and has significant therapeutic and biomarker applications. Further research is needed to fully understand its functions and potential therapeutic uses.

Protein Name: NADH:ubiquinone Oxidoreductase Subunit A3

Functions: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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