Unlocking the Potential of NDUFA12 as a Drug Target and Biomarker

Target Name: NDUFA12

NCBI ID: G55967

NDUFA12

Unlocking the Potential of NDUFA12 as a Drug Target and Biomarker

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 (NDUFA12) is a protein that plays a crucial role in the electron transport chain of the mitochondria. It is a key enzyme in the production of reactive oxygen species (ROS) that can cause damage to cellular components and contribute to various diseases, including aging, neurodegenerative diseases, and diseases associated with oxidative stress.

TheNDUFA12 gene has been well characterized, and several studies have identified its various isoforms.NDUFA12 is composed of two subunits, NDUFA12A and NDUFA12B, which contain distinct functional domains.NDUFA12A is the catalytic subunit, while NDUFA12B is the regulatory subunit.NDUFA12B contains a C-terminal domain that is involved in the regulation of its activity, while NDUFA12A contains a N-terminal domain that is involved in the recognition of its target molecules.

Despite its importance in the electron transport chain, little is known about the specific functions of NDUFA12.NDUFA12 has been shown to interact with various cellular components, including co-factors, vitamins, and minerals. It has also been shown to play a role in various cellular processes, including the production of ROS, the detoxification of xenobiotics, and the regulation of cellular signaling pathways.

The Potential of NDUFA12 as a Drug Target

The identification of NDUFA12 as a potential drug target is based on its unique structure and its involvement in various cellular processes.NDUFA12 has been shown to interact with various proteins, including superoxide dismutase (SOD) enzymes, which are involved in the detoxification of ROS. Therefore, targeting NDUFA12 may be an effective way to treat diseases associated with oxidative stress, such as neurodegenerative diseases, aging, and cancer.

NDUFA12 has also been shown to play a role in the production of ROS, which can contribute to various cellular stress responses, including the production of reactive oxygen species (ROS) that can cause damage to cellular components and contribute to the development of oxidative stress-induced diseases. Therefore, targeting NDUFA12 may also be an effective way to treat diseases associated with oxidative stress, such as cancer, neurodegenerative diseases, and aging.

The Role of NDUFA12 as a Biomarker

The detection of NDUFA12 levels in various biological samples, such as tissues, fluids, and cells, can be used as a biomarker to assess the level of oxidative stress in the body.NDUFA12 has been shown to increase in the levels of various tissues and biological samples in response to oxidative stress, such as cancer cells, neurodegenerative diseases, and aging. Therefore, the levels of NDUFA12 can be used as a biomarker to diagnose and monitor these diseases.

In addition, the level of NDUFA12 has been shown to be affected by various factors, including lifestyle, environmental factors, and medications. For example, the levels of NDUFA12 have been shown to be decreased in individuals with certain lifestyle factors, such as smoking and excessive alcohol consumption. Similarly, the levels of NDUFA12 have been shown to be increased in individuals exposed to certain environmental factors, such as air pollution and radiation.

Conclusion

NDUFA12 is a protein that plays a crucial role in the electron transport chain of the mitochondria and has been shown to interact with various cellular components and participate in various cellular processes.The identification of NDUFA12 as a potential drug target and biomarker suggests that it may be an effective way to treat diseases associated with oxidative stress, such as neurodegenerative diseases, aging, and cancer. Further research is needed to fully understand the functions

Protein Name: NADH:ubiquinone Oxidoreductase Subunit A12

Functions: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

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