Unlocking the Potential of NDUFA13: A Promising Drug Target and Biomarker

Target Name: NDUFA13

NCBI ID: G51079

NDUFA13

Unlocking the Potential of NDUFA13: A Promising Drug Target and Biomarker

Introduction

The novel protein NDUFA13, also known as CGI-39, has garnered significant interest due to its unique structure and various bio-chemical properties. NDUFA13 is a 21-kDa acidic protein that is expressed in various tissues, including the brain, heart, and kidneys. Its function in these organisms is still poorly understood, but its potential role in disease pathology is being investigated. As a result, NDUFA13 has emerged as a promising drug target and biomarker.

TheNGene: NDUFA13

NDUFA13 is a member of the N-terminal G protein-coupled receptor (NGRC) family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling. NGRCs are involved in various physiological processes, including sensory perception, neurotransmitter signaling , and cellular signaling adaptations.NDUFA13 is specifically characterized by its unique N-terminus, which contains a characteristic conserved domain known as the N-terminal hypervariable region (HVR).

HVRs are regions of the protein that are highly variable and can differ among different species. In NDUFA13, the HVR is located from the A1A site (residue 13) to the C3C site (residue 20). This region is known for its ability to interact with various ligands, including small molecules, peptides, and even proteins. The HVR interacts with the protein's catalytic activity, leading to the formation of a stable complex that enhances the activity of NDUFA13.

Drug Target Potential

The drug targeting potential of NDUFA13 is high due to its unique HVR and its involvement in various cellular signaling pathways. NDUFA13 has been shown to play a critical role in neurotransmitter signaling, particularly in the regulation of extracellular signaling proteins (ESPs) such as neurotransmitter receptors .NDUFA13 has been shown to interact with various ESPs, including the尾2-adrenergic receptor (尾2AR), the GABA-伪 receptor, and the neurotransmitter receptor N receptor.

In addition to its role in neurotransmission, NDUFA13 has also been shown to participate in various cellular signaling pathways that are critical for cell survival and reproduction. NDUFA13 has been shown to be involved in the regulation of cell adhesion, migration, and the cytoskeleton.

Biomarker Potential

The potential use of NDUFA13 as a biomarker is high due to its unique expression and its involvement in various cellular signaling pathways. NDUFA13 has been shown to be highly expressed in various tissues, including the brain, heart, and kidneys. Its expression is also regulated by various factors, including growth factors, hormones, and diseases, which could make it an attractive biomarker for various diseases.

NDUFA13 has also been shown to play a critical role in the regulation of various signaling pathways that are involved in cancer progression. Its expression has been shown to be associated with the development and progression of various cancers, including neurofibromatosis, neuroendocrine tumors, and uveal cancer.

Conclusion

In conclusion, NDUFA13 is a promising drug target and biomarker due to its unique structure and its involvement in various cellular signaling pathways. Its potential as a drug target is high due to its role in neurotransmission, its involvement in various signaling pathways, and its association with the development and progression of various diseases. Its potential as a biomarker is also high due to its unique expression and its involvement in various cellular signaling pathways, making it an attractive tool for the study of various diseases.

NGene: NDUFA13

TheNGene: NDUFA13 is a 21-kDa acidic protein that is expressed in various tissues

Protein Name: NADH:ubiquinone Oxidoreductase Subunit A13

Functions: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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