NDUFA4's Role in Cell-Cell Adhesion, Signaling Pathways and Pain Perception

Target Name: NDUFA4

NCBI ID: G4697

NDUFA4

NDUFA4's Role in Cell-Cell Adhesion, Signaling Pathways and Pain Perception

NDUFA4 (FLJ27440) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the N-cadherin gene family, which is known for its role in cell-cell adhesion.

The N-cadherin gene family has been implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. The encoded protein, NDUFA4, has been shown to play a role in several of these conditions.

One of the main functions of NDUFA4 is its role in cell-cell adhesion. This protein helps to maintain the integrity of the blood-brain barrier, which is responsible for controlling the movement of substances into and out of the brain.NDUFA4 is also involved in the regulation of cell signaling pathways, which are important for many cellular processes.

In addition to its role in cell-cell adhesion and signaling pathways, NDUFA4 is also implicated in the development and progression of several diseases. For example, studies have shown that NDUFA4 is overexpressed in the brains of individuals with Alzheimer's disease, a progressive neurodegenerative disorder.

Furthermore,NDUFA4 has also been shown to be involved in the regulation of pain perception. Studies have shown that NDUFA4 is involved in the production of pain signals in the brain, which can help to contribute to the development of chronic pain conditions.

In conclusion, NDUFA4 is a protein that has been shown to play a role in a variety of conditions, including cell-cell adhesion, signaling pathways, and the regulation of pain perception. Further research is needed to fully understand the role of NDUFA4 in these conditions and to develop effective treatments.

Protein Name: NDUFA4 Mitochondrial Complex Associated

Functions: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:22902835). NDUFA4 is required for complex IV maintenance (PubMed:22902835)

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