NEDD8: A Neurotransmitter Enaminate Regulating Synaptic Plasticity and Cell Communication

Target Name: NEDD8

NCBI ID: G4738

NEDD8

NEDD8: A Neurotransmitter Enaminate Regulating Synaptic Plasticity and Cell Communication

NEDD8, a protein known as a neurotransmitter enaminate, is a crucial molecule in the nervous system that plays a critical role in the development and maintenance of neural circuits. NEDD8 is a small non-coding RNA molecule that is synthesized from the amino acid Lysine by the enzyme NEDD8-containing protein (NEDD8-PPI). NEDD8 is highly expressed in the brain and is involved in a wide range of physiological processes, including neuronal communication, synaptic plasticity, and mood regulation.

One of the defining features of NEDD8 is its role in synaptic plasticity, which is the ability of the nervous system to change and adapt over time. NEDD8 is involved in the regulation of synaptic plasticity by controlling the activity of enzymes that modify the structure and function of synapses. These enzymes include the neurotransmitter-associated protein (NAAP), which is involved in the regulation of neurotransmitter release, and the protein synapsin, which is involved in the structure and function of synapses.

NEDD8 is also involved in the regulation of neuronal communication, which is the exchange of information between neurons that is critical for the functioning of the nervous system. NEDD8 is regulated by the neurotransmitter serotonin, which is involved in the regulation of mood, appetite, and sleep. Serotonin release is regulated by the NEDD8-associated protein (NASP), which is a negative regulator of serotonin release.

In addition to its role in synaptic plasticity and neuronal communication, NEDD8 is also involved in the regulation of inflammation and stress responses. NEDD8 is regulated by the transcription factor

Protein Name: NEDD8 Ubiquitin Like Modifier

Functions: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:15242646, PubMed:14690597). Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:20688984). Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity (PubMed:15242646). Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (PubMed:14690597)

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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