Target Name: GPR137
NCBI ID: G56834
Review Report on GPR137 Target / Biomarker Content of Review Report on GPR137 Target / Biomarker
GPR137
Other Name(s): Integral membrane protein GPR137 (isoform 2) | TM7SF1L1 | Integral membrane protein GPR137 (isoform 3) | Integral membrane protein GPR137 isoform X1 | Transmembrane 7 superfamily member 1-like 1 protein | GPR137 variant 3 | G protein-coupled receptor 137, transcript variant 2 | G137A_HUMAN | Integral membrane protein GPR137 | Integral membrane protein GPR137 (isoform 1) | GPR137A | GPR137 variant 2 | G protein-coupled receptor 137, transcript variant 3 | G protein-coupled receptor 137, transcript variant 1 | transmembrane 7 superfamily member 1-like 1 protein | G protein-coupled receptor 137 | GPR137 variant 1 | C11orf4

Study: GPR137 Regulates Blood Pressure and Plays Role in Pain, Appetite and Metabolism

GPR137, also known as Integral membrane protein GPR137 (isoform 2), is a protein that is expressed in various tissues and cells in the body. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play an important role in cellular signaling.

GPR137 is a 21-kDa protein that is expressed in the brain, heart, kidneys, and intestine. It is primarily localized to the endothelial cells of the blood vessels, where it is involved in the regulation of blood pressure. GPR137 has been shown to play a role in the regulation of blood pressure by increasing the sensitivity of blood vessels to the effects of angiotensin II, a hormone that causes blood vessels to constrict and blood pressure to rise.

GPR137 is also known as ISOform 2 because it is one of two isoforms of the GPCR that have been identified. The other is ISOform 1, which is also known as GPR137L. Both isoforms are produced by alternative splicing of the same gene. GPR137L is predominantly expressed in the liver and pancreas, while GPR137 is mainly expressed in the brain, heart, and kidneys.

GPR137 has been shown to interact with several different molecules, including angiotensin II, which is a hormone that is produced by the adrenal gland in response to high blood pressure. Angiotensin II causes blood vessels to constrict and blood pressure to rise, which can lead to cardiovascular disease. By interacting with angiotensin II, GPR137 has been shown to regulate the blood pressure and protect against the negative effects of this hormone.

In addition to its role in blood pressure regulation, GPR137 has also been shown to play a role in the regulation of pain. It is a potent negative regulator of pain perception, which means that it can reduce the sensitivity of pain signals. This is important because pain can be a powerful motivator for the body to seek out medical attention and seek relief.

GPR137 has also been shown to play a role in the regulation of appetite and metabolism. It is expressed in the hypothalamus, which is a region of the brain that is involved in the regulation of hormones that control appetite and metabolism. GPR137 has been shown to interact with the hormone leptin, which is produced by the body's fat cells. This interaction between GPR137 and leptin suggests that GPR137 may be involved in the regulation of body weight and composition.

GPR137 is also a potential drug target because of its involvement in several important biological processes. For example, it is a good candidate for treatment with Angiotensin II antagonists, which are drugs that block the effects of angiotensin II. Angiotensin II antagonists are currently used to treat hypertension and heart failure, and they have been shown to be effective in these conditions. By blocking the effects of angiotensin II, GPR137 may be able to reduce the risk of cardiovascular disease associated with this hormone.

In addition, GPR137 may also be a good candidate for treatment with drugs that target the regulation of pain. GPR137 has been shown to play a role in the regulation of pain perception, and drugs that block its effects may be effective in treating chronic pain. For example, GPR137 antagonists may be

Protein Name: G Protein-coupled Receptor 137

Functions: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes (PubMed:31036939). May play a role in autophagy (PubMed:31036939)

The "GPR137 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR137 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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