KRTAP27-1: A Potential Drug Target for Pain Perception and Neuroinflammation

Target Name: KRTAP27-1

NCBI ID: G643812

KRTAP27-1

KRTAP27-1: A Potential Drug Target for Pain Perception and Neuroinflammation

KRTAP27-1 (KAP27.1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Kallikrein-related peptidases (KAPs) family 27, which is characterized by the presence of a specific catalytic center composed of a tryptophan residue and a hypervariable region (HVR).

KRTAP27-1 has been identified as a potential drug target due to its unique structure and the functions it is known to have in various physiological processes. One of the most significant functions of KRTAP27-1 is its role in the regulation of pain perception and neuroinflammation.

KRTAP27-1 is known to be involved in the regulation of pain perception by participating in the nociceptive signaling pathway. This pathway is responsible for transmitting information from the pain-producing body to the central nervous system, leading to the sensation of pain. KRTAP27-1 has been shown to regulate the expression of genes involved in pain perception, as well as the release of pain-related neurotransmitters from pain neurons.

In addition to its role in pain perception, KRTAP27-1 is also involved in the regulation of neuroinflammation. Neuroinflammation is a type of inflammation that occurs in the brain and other nervous system tissues, and can be caused by a variety of factors, including trauma, infection, and disease.

KRTAP27-1 has been shown to be involved in the regulation of neuroinflammation by participating in the immune response. It has been shown to interact with immune cells and molecules involved in inflammation, including T cells, NK cells, and microglia. Additionally, KRTAP27-1 has been shown to regulate the production of pro-inflammatory cytokines, which can contribute to the inflammation response.

KRTAP27-1 is also involved in the regulation of cell survival and proliferation. It has been shown to play a role in the regulation of cell survival and proliferation by interacting with various cellular signaling pathways, including the TGF-β pathway and the Wnt pathway.

In conclusion, KRTAP27-1 is a protein that is expressed in various tissues of the body and is involved in a variety of physiological processes. Its unique structure and functions make it a potential drug target for a variety of therapeutic applications. Further research is needed to fully understand the role of KRTAP27-1 in pain perception, neuroinflammation, and cell survival and proliferation.

Protein Name: Keratin Associated Protein 27-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP27-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP27-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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