KRTAP4-1: A Potential Drug Target Or Biomarker for Various Diseases

Target Name: KRTAP4-1

NCBI ID: G85285

KRTAP4-1

KRTAP4-1: A Potential Drug Target Or Biomarker for Various Diseases

KRTAP4-1 (KRTAP4-10) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the known as the KRTAS gene family, which encodes for proteins that are involved in various cellular processes, including cell signaling, migration, and invasion.

Recent studies have identified KRTAP4-1 as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and respiratory infections. Its potential as a drug target is due to its involvement in several cellular processes that are associated with the development and progression of these diseases.

One of the key functions of KRTAP4-1 is its role in cell signaling. It is a negative regulator of the protein TrkA, which is involved in the formation of stress-induced intracellular signaling pathways. These pathways are important for responding to various stressors, including ionizing radiation, UV radiation, and chemotherapy drugs. By regulating TrkA, KRTAP4-1 helps to prevent excessive signaling, which can lead to cellular responses that are harmful to the body.

KRTAP4-1 has also been shown to be involved in the regulation of cell migration and invasion. It is a critical regulator of the protein Traf6, which is involved in the process of cell migration and the formation of tight junctions, which are important for maintaining tissue structure and function. Traf6 is a transcription factor that is activated by various growth factors, including PDGF, which is a key signaling molecule in many diseases, including cancer.

In addition to its role in cell signaling and migration, KRTAP4-1 is also involved in the regulation of inflammation. It is a positive regulator of the protein NF-kappa-B, which is involved in the production of pro-inflammatory cytokines. NF-kappa-B is a transcription factor that is activated by various stressors, including bacterial toxins and viruses. By regulating NF-kappa-B, KRTAP4-1 helps to promote an inflammatory response that is important for defending the body against infection.

KRTAP4-1 has also been shown to be involved in the regulation of cell apoptosis, which is the process by which cells die in response to various stressors. It is a negative regulator of the protein Bcl-2, which is involved in the regulation of cell apoptosis. Bcl-2 is a transcription factor that is activated by various stressors, including chemotherapy drugs and radiation. By regulating Bcl-2, KRTAP4-1 helps to prevent excessive cell apoptosis, which can lead to the loss of cells that are necessary for maintaining tissue function.

In conclusion, KRTAP4-1 is a protein that is involved in several cellular processes that are important for the development and progression of various diseases. Its potential as a drug target or biomarker is due to its involvement in these processes, as well as its regulation of cell signaling, migration, and invasion. Further research is needed to fully understand the role of KRTAP4-1 in diseases and to develop effective treatments based on its potential as a drug target or biomarker.

Protein Name: Keratin Associated Protein 4-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP4-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP4-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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