GPR135: A Potential Drug Target for Various Physiological Processes
GPR135: A Potential Drug Target for Various Physiological Processes
G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPCRs are also known as GPRs and their gene symbol is GPR.
GPR135 is a GPCR that is expressed in various tissues and cells in the body. It is a 17-kDa protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain of GPR135 contains a N-terminus that is involved in protein-protein interactions and a C-terminus that contains a G-type 伪-helix.
The transmembrane region of GPR135 contains four transmembrane spanning regions (TMRs). The first TMR is located at the N-terminus of the protein and is composed of a single alpha-helix. The second TMR is located in the middle of the protein and is composed of a double alpha-helix. The third TMR is located at the C-terminus of the protein and is composed of a single alpha-helix. The fourth TMR is located in the middle of the protein and is composed of a double alpha- spiral.
The intracellular domain of GPR135 contains a carboxylic acid residue that is involved in the formation of a protein-protein interaction (PPI). This interaction may play a role in the function of GPR135 in the cell.
GPR135 is involved in various physiological processes in the body. It is involved in the regulation of pain perception, anxiety, and depression. GPR135 is also involved in the regulation of neurotransmitter release from neuronal cells, including dopamine, norepinephrine and glutamine Acid. In addition, GPR135 is also involved in regulating immune cell functions, including the activation of T cells.
In recent years, researchers have discovered that GPR135 has important prospects in the field of drug research and development. Due to its important role in cell signaling, GPR135 is considered a potential drug target (or biomarker).
Currently, a variety of drugs are in clinical trials to treat GPR135-related diseases. Among them, the most important drugs are opioids, the most widely used analgesics. GPR135 plays an important role in opioids, particularly in the therapeutic effects of morphine. By blocking GPR135, morphine reduces pain.
In addition to analgesic drugs, GPR135 is also used as a treatment for mood disorders such as depression and anxiety. Research shows that GPR135 works similarly to antidepressant and anti-anxiety drugs in depression and anxiety. By increasing the activity of GPR135, the patient's emotional state can be improved.
Additionally, GPR135 is used as a drug to treat autoimmune diseases in the immune system. GPR135's role in immune cell activation makes it a potential drug for the treatment of autoimmune diseases.
GPR135 is a very important protein that is of great significance in drug development and treatment of various physiological diseases. As technology continues to advance, researchers will continue to study the potential of GPR135 in drug development and find more effective treatments.
Protein Name: G Protein-coupled Receptor 135
Functions: Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538)
The "GPR135 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR135 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1
