Target Name: GPN1
NCBI ID: G11321
Review Report on GPN1 Target / Biomarker Content of Review Report on GPN1 Target / Biomarker
GPN1
Other Name(s): XPA binding protein 1, GTPase | MBDin | ATP(GTP)-binding protein | MBDIN | XPA-binding protein 1 | NTPBP | ATPBD1A | GPN-loop GTPase 1 | GPN1_HUMAN | RPAP4 | XAB1 | GPN1 variant 1 | RNA polymerase II associated protein 4 | GPN-loop GTPase 1 isoform a | MBD2-interacting protein | RNAPII-associated protein 4 | GPN-loop GTPase 1, transcript variant 1

Understanding The Role of GPN1 in Cellular Signaling and Disease

GPN1 (GTPase binding protein 1), also known as XPA binding protein 1, is a protein that plays a crucial role in various cellular processes. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a significant role in cellular signaling. GPN1 is expressed in many tissues and is involved in various cellular processes, including cell signaling, cell division, and cell survival.

GPN1 is a protein that can be targeted as a drug or a biomarker due to its unique structure and function. Its unique protein structure, which consists of a long extracellular domain, a short transmembrane domain, and a long intracellular domain, makes it an attractive target for small molecules. Additionally, its role in various cellular processes and its expression in many tissues make it an attractive biomarker for various diseases.

One of the key functions of GPN1 is its role in cell signaling. GPN1 is involved in various signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway. These signaling pathways are involved in various cellular processes, including cell growth, cell differentiation, and cell survival.

In addition to its role in cell signaling, GPN1 is also involved in cell division. It is a critical protein for cell division and has been shown to play a role in the regulation of cell cycle progression. GPN1 has been shown to interact with various oncogenic signaling pathways, including the TGF-β pathway, which is involved in cancer development.

GPN1 is also involved in cell survival. It has been shown to play a role in the regulation of cellular stress responses, which are important for the survival of cells under various stress conditions. Additionally, GPN1 has been shown to play a role in the regulation of cellular apoptosis, which is the process by which cells die under certain conditions.

GPN1 is a protein that has been shown to be involved in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, GPN1 has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Additionally, GPN1 has been shown to be involved in the development and progression of cancer, including breast and ovarian cancer.

In conclusion, GPN1 is a protein that plays a crucial role in various cellular processes and is involved in various diseases. Its unique protein structure and function make it an attractive target for small molecules and a potential drug or biomarker. Further research is needed to fully understand the role of GPN1 in various cellular processes and its potential as a drug or biomarker.

Protein Name: GPN-loop GTPase 1

Functions: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119)

The "GPN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein