GPR132: A Potential Drug Target and Biomarker for Neurological Disorders
GPR132: A Potential Drug Target and Biomarker for Neurological Disorders
GPR132, also known as Probable G-Protein Coupled Receptor 132, is a protein that is expressed in various tissues throughout the body. It is a member of the G-protein coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play an important role in cellular signaling. GPR132 is primarily expressed in the brain and is involved in a wide range of physiological processes, including brain development, neurotransmitter signaling, and cell survival.
GPR132 is a potential drug target due to its involvement in neurotransmission. It is known to play a role in the regulation of neurotransmitter release from neurons, which is critical for various behaviors and cognitive processes. Additionally, GPR132 has been shown to interact with dopamine, a well-known neurotransmitter that is involved in motor control, mood regulation, and other essential functions.
GPR132 is also a potential biomarker for various neurological disorders. For example, GPR132 has been shown to be expressed abnormally in the brains of individuals with Alzheimer's disease, a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques. Additionally, GPR132 has been shown to be involved in the regulation of neuroinflammation, which is a hallmark feature of many neurodegenerative diseases.
In addition to its potential drug and biomarker applications, GPR132 is also of interest as a potential therapeutic target for other conditions. For example, GPR132 has been shown to play a role in the regulation of neuronal excitability, which is critical for the function of many neurons in the brain. Additionally, GPR132 has been shown to interact with other proteins that are involved in neuronal function, including neurotransmitter receptors and ion channels. This suggests that GPR132 may be involved in the regulation of a wide range of neuronal processes, including neurotransmission , neuronal excitability, and neuronal survival.
GPR132 is also of interest as a potential target for drug development due to its well-characterized structure and its potential role in neurotransmission. GPR132 is a small, transmembrane protein that contains a single transmembrane domain and a single intracellular loop. This allows for the production of highly purified recombinant proteins that can be used for drug development. Additionally, the well-characterized structure of GPR132 allows for the design of small molecules that can interact with specific residues and potentially modulate its function.
In conclusion, GPR132 is a protein that is of interest as a potential drug target due to its involvement in neurotransmission and its potential as a biomarker for various neurological disorders. Its well-characterized structure and its potential role in the regulation of neuronal excitability make it an attractive target for drug development. Further research is needed to fully understand the function of GPR132 and its potential as a therapeutic target.
Protein Name: G Protein-coupled Receptor 132
Functions: May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity
The "GPR132 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR132 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1
