Target Name: GPKOW
NCBI ID: G27238
Review Report on GPKOW Target / Biomarker Content of Review Report on GPKOW Target / Biomarker
GPKOW
Other Name(s): G patch domain-containing protein 5 | Protein MOS2 homolog | GPATCH5 | G patch domain and KOW motifs-containing protein | Spp2 | protein MOS2 homolog | Protein T54 | GPKOW_HUMAN | G-patch domain-containing protein 5 | T54 | GPATC5 | Mos2 | G-patch domain and KOW motifs | G-patch domain and KOW motifs-containing protein

GPKOW: A GPCR Target for Small Molecules and Therapeutic Development

G-protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPKOW (G patch domain-containing protein 5) is a GPCR that is expressed in various tissues and cells in the body. Although GPKOW has been studied extensively, its functions and potential drug targets are not well understood. In this article, we will explore the biology of GPKOW and its potential as a drug target.

Structure and Function

GPKOW is a 120-kDa protein that is composed of an extracellular region, a transmembrane region, and an intracellular region. The extracellular region consists of a N-terminal region that contains a putative GPCR signaling domain, a transmembrane region that includes an extracellular loop and a cytoplasmic tail, and an intracellular region that contains a unique N-terminal domain that is unique among GPCRs.

The N-terminal domain of GPKOW is rich in conserved amino acid sequences, including two conserved 伪-helices and two conserved 尾-coils. These 伪-helices and 尾-curls form a large hydrophobic core that provides a stable basis for intermolecular interactions. In addition, the N-terminal domain also contains a highly conserved lysine-glutamate binding site, which is a key site for the interaction between GPCR and ligands.

GPKOW functions as a negative regulator of the RGY2 receptor, which is involved in pain perception and neurotransmission. The RGY2 receptor is a GPCR that is expressed in various tissues, including brain, muscle, and sensory neurons. GPKOW functions as a negative regulator by promoting the degradation of RGY2 receptor, which leads to decreased signaling through the RGY2 receptor.

Drug Targets

GPKOW has been identified as a potential drug target due to its unique structure and function. The N-terminal domain of GPKOW is rich in conserved amino acid sequence, which makes it a promising target for small molecules. Additionally, the highly conserved lysine -The glutamate binding site makes GPKOW a highly efficient substrate for protein-ligand interactions.

Currently, a variety of drugs are used to treat GPKOW-related diseases, such as neuralgia, dysmenorrhea, and diabetes. These drugs work together to reduce signaling in neurons and muscle cells by inhibiting the function of GPKOW. However, due to the key role of GPKOW in drug screening and therapeutic response, an in-depth understanding of the functional and pharmacodynamic properties of GPKOW remains one of the hot topics of current research.

Conclusion

GPKOW is a GPCR that has been extensively studied for its functions and potential drug targets. Its unique structure and function make it a promising target for small molecules. Currently, multiple drugs are used to treat GPKOW-related diseases, but an in-depth understanding of GPKOW Its functional and pharmacodynamic properties are still one of the hot topics of current research. In the future, we will further study the functional and pharmacodynamic properties of GPKOW to develop new treatments and drugs.

Protein Name: G-patch Domain And KOW Motifs

Functions: RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

The "GPKOW Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPKOW comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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