Regulation of MiRNA Levels By Trav34: Potential Cancer Therapies

Target Name: TRAV34

NCBI ID: G28648

TRAV34

Other Name(s): TCRAV26S1 | T cell receptor alpha variable 34 | TCRAV34S1

Regulation of MiRNA Levels By Trav34: Potential Cancer Therapies

Trav34 (TCRAV26S1) is a drug target (or biomarker) that has been identified and characterized in various studies. Trav34 is a small non-coding RNA molecule that is located in the nuclear pericentromeric region of the chromosome 17.

The pericentromeric region is a region of the chromosome that plays a crucial role in the proper formation of the chromatin structure. This region is also home to a variety of non-coding RNAs, including Trav34, which is expressed in nearly all human tissues and is involved in various cellular processes.

One of the key functions ofTrav34 is its role in the regulation of gene expression. Specifically, Trav34 has been shown to act as a negative regulator of the gene encoding the protein known as p53. Thep53 gene is a well-known tumor suppressor gene that is involved in the regulation of various cellular processes, including DNA replication, apoptosis, and cell growth.

In addition to its role in gene regulation, Trav34 has also been shown to play a role in the regulation of microRNA (miRNA) levels. Specifically, Trav34 has been shown to act as a negative regulator of the miRNA molecule known as miR-18a, which is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival.

The role of Trav34 in the regulation of miRNA levels is of particular interest, as miRNA molecules have been shown to play a crucial role in the regulation of cellular processes and are often involved in the development and progression of various diseases, including cancer. Therefore, the regulation of Trav34 by miR-18a provides insight into the mechanisms underlying the regulation of miRNA levels and the potential implications for the development of cancer.

In conclusion, Trav34 is a drug target (or biomarker) that has been identified and characterized in various studies. Trav34 is involved in the regulation of gene expression and the regulation of miRNA levels, and its regulation by miR-18a provides insight into the mechanisms underlying the regulation of miRNA levels and the potential implications for the development of cancer. Further research is needed to fully understand the role of Trav34 in cellular processes and its potential as a drug target.

Protein Name: T Cell Receptor Alpha Variable 34

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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