Trav3: A Protein of Interest for Drug Targeting and Biomarker Development

Target Name: TRAV3

NCBI ID: G28690

TRAV3

Other Name(s): TCRAV16S1 | T cell receptor alpha variable 3 | TCRAV3S1

Trav3: A Protein of Interest for Drug Targeting and Biomarker Development

Trav3 (TcRav16S1) is a protein that is expressed in various tissues of the body, including the brain, pancreas, and heart. It is a member of the T-cell receptor (TCR) family, which is a group of transmembrane proteins that play a critical role in cell signaling.

One of the functions of Trav3 is its role in cell signaling. It is involved in the development and maintenance of the immune response, as well as in the regulation of inflammation. Trav3 has been shown to play a key role in the regulation of T cell development and function, and it has been implicated in a number of diseases, including cancer, autoimmune diseases, and neurodegenerative disorders.

In addition to its role in cell signaling, Trav3 is also of interest as a potential drug target. Researchers have identified several potential drug candidates that can inhibit Trav3, and these drugs have been shown to have a range of potential therapeutic effects, including the treatment of cancer, autoimmune diseases, and neurodegenerative disorders.

One of the advantages of targeting Trav3 is that it is a protein that is expressed in a wide range of tissues, which makes it an attractive target for drugs that can be used to treat a broad range of conditions. Additionally, Trav3 is a protein that is highly conserved across different species, which suggests that it is a reliable target for drugs that can be effective in a variety of species.

Another potential advantage of targeting Trav3 is its role in the regulation of cell signaling. Trav3 has been shown to play a key role in the development and maintenance of the immune response, and it is involved in the regulation of T cell development and function. This suggests that targeting Trav3 with drugs that can disrupt its function in these ways may have a range of potential therapeutic effects.

In addition to its potential therapeutic effects, Trav3 is also of interest as a potential biomarker. Researchers have shown that Trav3 is expressed in a variety of tissues and that it is involved in the regulation of cell signaling. This suggests that Trav3 may be a useful biomarker for a range of diseases, including cancer, autoimmune diseases, and neurodegenerative disorders.

Overall, Trav3 is a protein that is of interest as a potential drug target and biomarker. Its role in cell signaling and its expression in a wide range of tissues make it an attractive target for drugs that can be used to treat a broad range of conditions. Additionally, its function in the regulation of the immune response and its potential as a biomarker for a range of diseases make it an important molecule to study further.

Protein Name: T Cell Receptor Alpha Variable 3

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRAV3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAV3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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