IL-1RAP: Key Regulator of Immune and Cardiovascular Systems (G3556)

Target Name: IL1RAP

NCBI ID: G3556

IL1RAP

IL-1RAP: Key Regulator of Immune and Cardiovascular Systems

IL-1RAP (Interleukin-1 Receptor-Activator Protein) is a protein that is expressed in various tissues throughout the body, including the immune system, heart, and kidneys. It is a key regulator of the immune response and has been implicated in a number of diseases, including cardiovascular disease and diabetes. In recent years, researchers have been interested in studying IL-1RAP as a potential drug target or biomarker, due to its unique structure and its ability to interact with various signaling pathways.

IL-1RAP is a protein that is composed of 21 kDa of extracellular domain and 5 kDa of intracellular domain. The extracellular domain is involved in the formation of IL-1RAP dimers, which are critical for its function. The intracellular domain contains a catalytic active site and several putative binding sites that are involved in the interaction with other proteins.

One of the most significant functions of IL-1RAP is its role in the regulation of the immune response. IL-1RAP has been shown to play a key role in the development and maintenance of inflammation. In addition, IL-1RAP has been shown to Regulate the production of pro-inflammatory cytokines, such as TNF-伪 and IL-1尾. These cytokines are important for the recruitment of immune cells to the site of inflammation and for the regulation of inflammation itself.

IL-1RAP is also involved in the regulation of cellular signaling pathways that are important for the development and maintenance of cardiovascular disease. For example, IL-1RAP has been shown to interact with the protein PDGF-BB and to regulate the tyrosine kinase activity of the transcription factor p21. These interactions are important for the regulation of cell proliferation and the formation of blood vessels, which are critical for cardiovascular disease.

In addition to its role in the immune and cardiovascular systems, IL-1RAP is also implicated in the development and maintenance of a number of other diseases. For example, IL-1RAP has been shown to be involved in the development of cancer, and to contribute to the regulation of the inflammatory response that is associated with cancer progression. In addition, IL-1RAP has been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Despite these promising findings, the role of IL-1RAP as a drug target or biomarker is still being studied. In addition to its potential as a therapeutic target, IL-1RAP is also a potential biomarker for a number of diseases. For example, the levels of IL-1RAP have been shown to be elevated in the brains of individuals with Alzheimer's disease, and to be associated with the progression of neurodegeneration in these individuals. In addition, the levels of IL-1RAP have been shown to be elevated in the blood of individuals with Parkinson's disease, and to be associated with the progression of neurodegeneration in these individuals.

In conclusion, IL-1RAP is a protein that is involved in a number of important biological processes, including the regulation of the immune response and the cardiovascular system. Its unique structure and its ability to interact with a variety of signaling pathways make it an attractive target for research and development as a drug or biomarker. Further studies are needed to fully understand the role of IL-1RAP in these processes and to determine its potential as a therapeutic or diagnostic tool.

Protein Name: Interleukin 1 Receptor Accessory Protein

Functions: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable)

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