Target Name: IL20
NCBI ID: G50604
Review Report on IL20 Target / Biomarker Content of Review Report on IL20 Target / Biomarker
IL20
Other Name(s): cytokine Zcyto10 | interleukin 20 | Interleukin 20, transcript variant 1 | MGC96907 | Interleukin-20 (isoform 1) | IL20 variant 1 | four alpha helix cytokine | Cytokine Zcyto10 | Interleukin-20 | Four alpha helix cytokine | IL20_HUMAN | ZCYTO10 | IL-20 | IL10D

IL20: A Potential Drug Target for Immune and Cancer-Related Diseases

IL20 (Interleukin-20) is a cytokine that plays a crucial role in the immune response and inflammation. It is produced by various types of immune cells, including T cells, NK cells, and macrophages. The cytokine is involved in the regulation of cellular processes such as cell growth, apoptosis, and cytokine signaling. It is also involved in the regulation of immune responses, including the regulation of inflammation and the modulation of immune tolerance.

IL20 has been identified as a potential drug target for various diseases, including cancer, autoimmune diseases, and respiratory infections. Its unique mechanism of action and its potential as a therapeutic agent make it an attractive target for researchers.

One of the key mechanisms by which IL20 contributes to the immune response is its role in the regulation of T cell development and function. T cells are a crucial type of immune cell that play a critical role in the regulation of adaptive immunity. They are responsible for recognizing and responding to foreign antigens, including viruses and bacteria. T cells are also involved in the regulation of cancer development and have been implicated in the development of various types of cancer.

IL20 plays a crucial role in the regulation of T cell development and function by regulating the expression of genes involved in T cell receptor (TCR) signaling. TCR is a transmembrane protein that is involved in the recognition of foreign antigens by T cells. The cytokine plays a crucial role in the regulation of TCR signaling by interacting with the tyrosine kinase receptor FGR1, which is involved in the regulation of T cell growth and differentiation.

IL20 is also involved in the regulation of T cell apoptosis, which is a critical process in the immune response. Apoptosis is the process by which cells undergo programmed cell death, which is necessary for the regulation of immune responses and the maintenance of tissue homeostasis. The cytokine plays a crucial role in the regulation of T cell apoptosis by interacting with the Bcl-2 protein, which is involved in the regulation of cell survival.

IL20 is also involved in the regulation of immune tolerance, which is the ability of the immune system to distinguish between self and non-self and to avoid attacking the body's own tissues. The cytokine plays a crucial role in the regulation of immune tolerance by interacting with thePD-1 gene, which is involved in the regulation of self-reactive T cell responses.

In addition to its role in T cell development and function, IL20 is also involved in the regulation of inflammation. The cytokine plays a crucial role in the regulation of inflammation by interacting with the nuclear factor kappa B (NFKB) signaling pathway. NFKB is a complex that is involved in the regulation of inflammation, cell survival, and apoptosis. The cytokine plays a crucial role in the regulation of NFKB signaling pathway by interacting with the p65 protein, which is a key component of the pathway.

IL20 is also involved in the regulation of cancer development. The cytokine plays a crucial role in the regulation of cancer development by interacting with the and TGF-beta signaling pathways. The and TGF-beta signaling pathways are involved in the regulation of cell growth, apoptosis, and angiogenesis, which are critical processes in cancer development. The cytokine plays a crucial role in the regulation of and TGF-beta signaling pathways by interacting with the SMAD signaling pathway, which is involved in the regulation of cell growth and apoptosis.

In conclusion, IL20 is a cytokine that plays a crucial role in the immune response and inflammation. Its unique mechanism of action and its potential as a therapeutic agent make it an attractive target for researchers. Further studies are needed to fully understand the role of IL20 in the regulation of T cell development and function, immune tolerance, and cancer development.

Protein Name: Interleukin 20

Functions: Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:17277128, PubMed:34403503). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed:17277128). Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed:28424238). Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020). Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed:23614738)

The "IL20 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IL20 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

IL20RA | IL20RB | IL21 | IL21-AS1 | IL21R | IL21R-AS1 | IL22 | IL22RA1 | IL22RA2 | IL23A | IL23R | IL24 | IL25 | IL26 | IL27 | IL27RA | IL2RA | IL2RB | IL2RG | IL3 | IL31 | IL31RA | IL32 | IL33 | IL34 | IL36A | IL36B | IL36G | IL36RN | IL37 | IL3RA | IL4 | IL4I1 | IL4R | IL5 | IL5RA | IL6 | IL6-AS1 | IL6R | IL6R-AS1 | IL6ST | IL6ST-DT | IL6STP1 | IL7 | IL7R | IL9 | IL9R | IL9RP3 | IL9RP4 | ILDR1 | ILDR2 | ILF2 | ILF3 | ILF3-DT | ILK | ILKAP | ILRUN | ILVBL | Imidazoline I2 receptor (I2) | Imidazoline I3 receptor (I3) | Imidazoline receptor | IMMP1L | IMMP2L | IMMT | IMMTP1 | Immunoglobulin A | Immunoglobulin E (IgE) | Immunoglobulin G | Immunoglobulin M | Immunoglobulin-Like Domain Containing Receptor | Immunoproteasome | IMP3 | IMP4 | IMPA1 | IMPA1P1 | IMPA2 | IMPACT | IMPDH1 | IMPDH1P10 | IMPDH1P6 | IMPDH2 | IMPG1 | IMPG2 | INA | INAFM1 | INAFM2 | INAVA | INCA1 | INCENP | INE1 | INE2 | INF2 | ING1 | ING2 | ING2-DT | ING3 | ING4 | ING5 | INGX | INHA