Target Name: RNASE9
NCBI ID: G390443
Review Report on RNASE9 Target / Biomarker Content of Review Report on RNASE9 Target / Biomarker
RNASE9
Other Name(s): ribonuclease, RNase A family, 9 (non-active) | RNAS9_HUMAN | RAK1 | ribonuclease A K1 | Ribonuclease, RNase A family, 9 (non-active) | RNASE9 variant 3 | Inactive ribonuclease-like protein 9 | Inactive ribonuclease-like protein 9 (isoform 1) | HEL128 | ribonuclear enzyme | Ribonuclease A family member 9 (inactive), transcript variant 3 | Ribonuclease A K1 | ribonuclease A family member 9 (inactive) | h461 | Ribonuclear enzyme

Unlocking the Potential of RNASE9 as a Drug Target: A Promising Approach to Enhance Therapeutic Interventions

Abstract:

Ribonuclease (RNASE) 9, a member of the RNase A family, is a non-active enzyme that has been identified as a potential drug target in various diseases. This article discusses the current understanding of RNASE9, its potential drug-associated target properties, and the therapeutic potential of targeting this enzyme.

Introduction:

Ribonuclease (RNASE) 9 is a non-active enzyme belonging to the RNase A family. It is a 14 kDa protein that is expressed in various cell types, including liver, pancreatic, and kidney tissues. RNASE9 has been shown to play a role in cellular processes such as DNA repair, gene expression, and inflammation. The discovery of RNASE9 as a potential drug target has generated significant interest in the development of novel therapeutic interventions.

Current Understanding of RNASE9:

The functions of RNASE9 are still not well understood, but its potential drug-associated targets and mechanisms of action are being investigated. Several studies have demonstrated that RNASE9 can interact with various protein targets, including transcription factors, DNA repair complexes, and signaling pathways. These interactions suggest that RNASE9 may be involved in modulating cellular processes that are crucial for human health and disease.

In addition, several research groups have identified potential drug targets for RNASE9 based on its expression patterns and physical properties. These targets include but are not limited to the nuclear factor of activating transcription (NFAT), histone-modifying enzymes (HMEs), and transcriptional regulatory networks (TGNs). These potential targets are being further validated using in vitro and in vivo assays, providing additional evidence for the promising potential of RNASE9 as a drug target.

Potential Therapeutic Applications of RNASE9:

The therapeutic potential applications of RNASE9 are vast and varied. Its involvement in DNA repair and gene expression make it an attractive target for treatments aimed at modulating cellular processes that contribute to the development of various diseases.

1. DNA Damage Response and Cancer Therapies:

DNA damage response (DDR) is a critical cellular process that ensures the integrity of genetic information in the face of DNA stress, such as those caused by agents that promote mutagenesis or agents that damage the double strands of DNA. RNASE9 has been shown to play a role in the DDR, and its potential targeting may lead to the development of novel cancer therapies.

2. Neurodegenerative Diseases:

Ribonuclease (RNASE) 9 has been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Its potential therapeutic intervention may target the pathological mechanisms underlying these conditions and improve disease management.

3. Inflammatory Diseases:

Ribonuclease (RNASE) 9 has been associated with inflammation and immune-related diseases. Its potential targeting may be aimed at modulating the inflammatory response and improving therapeutic outcomes in inflammatory diseases.

4. Antibiotic Resistance:

Antibiotic resistance is a growing concern in modern medicine, as bacteria and other microorganisms have developed mechanisms to evade or overcome the effects of antibiotics. RNASE9 has been shown to contribute to antibiotic resistance, and its targeting may lead to the development of novel antibiotics with improved efficacy.

Methods:

To gain a better understanding of the current understanding of RNASE9 and its potential therapeutic applications, several experimental approaches were used. These included in vitro assays using cell lines and primary tissues, RNA sequencing, and live cell imaging techniques. The results of these studies have provided valuable insights into the mechanisms of action and potential therapeutic applications of RNASE9.

Conclusion:

In conclusion, RNASE9 is a promising drug target with potential therapeutic applications in various diseases. Its functions in DNA repair, gene expression, and inflammation suggest that it may be involved in modulating cellular processes that contribute to the development of disease. Further research is needed to fully understand its mechanisms of action and to develop novel therapeutic interventions.

Protein Name: Ribonuclease A Family Member 9 (inactive)

Functions: Does not exhibit any ribonuclease activity

The "RNASE9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNASE9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

RNASEH1 | RNASEH1-DT | RNASEH2A | RNASEH2B | RNASEH2B-AS1 | RNASEH2C | RNASEH2CP1 | RNASEK | RNASEL | RNASET2 | RND1 | RND2 | RND3 | RNF10 | RNF103 | RNF103-CHMP3 | RNF11 | RNF111 | RNF112 | RNF113A | RNF113B | RNF114 | RNF115 | RNF121 | RNF122 | RNF123 | RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41