Target Name: NDUFS1
NCBI ID: G4719
Review Report on NDUFS1 Target / Biomarker Content of Review Report on NDUFS1 Target / Biomarker
NDUFS1
Other Name(s): NADH-coenzyme Q reductase | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (isoform 1) | CI-75k | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (isoform 2) | PRO1304 | NDUFS1 variant 5 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (isoform 5) | NDUFS1 variant 2 | NADH:ubiquinone oxidoreductase core subunit S1, transcript variant 2 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | CI-75kD | Complex I, mitochondrial respiratory chain, 75-kD subunit | Complex I-75kD | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit | CI-75Kd | NDUS1_HUMAN | MC1DN5 | NADH:ubiquinone oxidoreductase core subunit S1 | NADH:ubiquinone oxidoreductase core subunit S1, transcript variant 1 | Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit | MGC26839 | NADH:ubiquinone oxidoreductase core subunit S1, transcript variant 5 | Complex I 75kDa subunit | complex I, mitochondrial respiratory chain, 75-kD subunit | complex I 75kDa subunit | NDUFS1 variant 1

NDUFS1: Key Enzyme in The NADH-coenzyme Q (NADH) Cycle

National Developmental Umbrella for Services (NDUFS1), also known as NADH-coenzyme Q (NADH) reductase, is a enzyme that plays a crucial role in the production of energy in the cells of all living organisms. It is a key enzyme in the citric acid cycle, also known as the Krebs cycle or TCA cycle, which is responsible for generating the energy-carrying molecule ATP fromADenosine (A) and Pyruvate (P).

NDUFS1 is a 22-kDa protein that is expressed in most organisms, including bacteria, archaea, and eukaryotes. It is a subunit of the E1 enzyme complex of the citric acid cycle and is located in the cytoplasm of the cell.

The NADH-coenzyme Q (NADH) cycle is a critical metabolic pathway that generates the majority of the energy for the cell. It is a linear reaction that involves the transfer of electrons from NAD+ (nicotinamide adenine dinucleotide) to FAD (flavin adenine dinucleotide) to produce NADH, which is then used to produce ATP through the process of oxidative phosphorylation.

NDUFS1 is a key enzyme in the NADH-coenzyme Q (NADH) cycle by participating in the transfer of electrons from NAD+ to FAD to produce NADH. The NADH cycle is the first step in the citric acid cycle and is critical for the production of ATP, which is the energy-carrying molecule of the cell.

NDUFS1 is a protein that is expressed in most organisms and is involved in the production of energy through the NADH-coenzyme Q (NADH) cycle. It is a subunit of the E1 enzyme complex of the NADH-coenzyme Q (NADH) cycle and is located in the cytoplasm of the cell.

The NADH-coenzyme Q (NADH) cycle is a critical metabolic pathway that generates the majority of the energy for the cell. It is a linear reaction that involves the transfer of electrons from NAD+ to FAD to produce NADH, which is then used to produce ATP through the process of oxidative phosphorylation.

NDUFS1 is a key enzyme in the NADH-coenzyme Q (NADH) cycle by participating in the transfer of electrons from NAD+ to FAD to produce NADH. The NADH cycle is the first step in the citric acid cycle and is critical for the production of ATP, which is the energy-carrying molecule of the cell.

NDUFS1 is a protein that is expressed in most organisms and plays a crucial role in the production of energy through the NADH-coenzyme Q (NADH) cycle. It is a subunit of the E1 enzyme complex of the NADH-coenzyme Q (NADH) cycle and is located in the cytoplasm of the cell.

The NADH-coenzyme Q (NADH) cycle is a critical metabolic pathway that generates the majority of the energy for the cell. It is a linear reaction that involves the transfer of electrons from NAD+ to FAD to produce NADH, which is then used to produce ATP through the process of oxidative phosphorylation.

NDUFS1 is a key enzyme in the NADH-coenzyme Q (NADH) cycle by participating in the transfer of electrons from NAD+ to FAD to produce NADH. The NADH cycle is the first step in the citric acid cycle and is critical for the production of ATP, which is the energy-carrying molecule of the cell.

In conclusion, NDUFS1 is a protein that is involved in

Protein Name: NADH:ubiquinone Oxidoreductase Core Subunit S1

Functions: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:31557978). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978)

The "NDUFS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NDUFS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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